Contrast effects of autophagy in the treatment of bladder cancer
| Autor: | Yener Kurman, Ece Konac, Sümer Baltaci |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Cell Survival media_common.quotation_subject Antineoplastic Agents Apoptosis Disease General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine medicine Autophagy Contrast (vision) Humans media_common Bladder cancer business.industry Treatment options medicine.disease Endoplasmic Reticulum Stress Oxidative Stress 030104 developmental biology Urinary Bladder Neoplasms Drug Resistance Neoplasm 030220 oncology & carcinogenesis Minireview business Signal Transduction |
| Zdroj: | Exp Biol Med (Maywood) |
| ISSN: | 1535-3699 |
| Popis: | Bladder canceris a disease that negatively affects patients’ quality of life, but treatment optionshave remained unchanged for a long time. Although promising results have been achievedwith current bladder cancer treatments, cancer recurrence, progression, and therapyresistance are the most severe problems preventing the efficiency of bladder cancertreatments. Autophagy refers to an evolutionarily conserved catabolic processin which proteins, damaged organelles, and cytoplasmic components are degradedby lysosomal enzymes. Autophagy regulates the therapeutic response to thechemotherapy drugs, thus determining the effect of therapy on cancer cells.Autophagy is a stress-induced cell survival mechanism and its excessivestimulation can cause resistance of tumor cells to therapeutic agents.Depending on the conditions, an increase in autophagy may cause treatmentresistance or autophagic cell death, and it is related to important anti-cancermechanisms, such as apoptosis. Therefore, understanding the roles of autophagyunder different conditions is important for designing effective anti-canceragents. The dual role of autophagy in cancer has attracted considerableattention in respect of bladder cancer treatment. In this review, we summarizethe basic characteristics of autophagy, including its mechanisms, regulation,and functions, and we present examples from current studies concerning the dualrole of autophagy in bladder cancer progression and therapy. |
| Databáze: | OpenAIRE |
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