Promising Perspective to Facioscapulohumeral Muscular Dystrophy Treatment: Nutraceuticals and Phytochemicals
| Autor: | Eyup Ilker Saygili, Eduardo Sobarzo-Sánchez, Devrim Demir-Dora, Zafer Cetin, Esra Küpeli Akkol, Sibel Berker Karauzum, Ceren Hangul, Gökhan Evcili |
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| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
congenital hereditary and neonatal diseases and abnormalities Phytochemicals Disease Bioinformatics chemistry.chemical_compound Nutraceutical DUX4 medicine Facioscapulohumeral muscular dystrophy Humans Pharmacology (medical) Muscle Skeletal Wasting Pharmacology Coenzyme Q10 Homeodomain Proteins business.industry Dystrophy General Medicine medicine.disease Muscular Dystrophy Facioscapulohumeral nervous system diseases Psychiatry and Mental health Neurology chemistry Phytochemical Dietary Supplements Neurology (clinical) medicine.symptom business |
| Zdroj: | Current neuropharmacology. 19(12) |
| ISSN: | 1875-6190 |
| Popis: | Facioscapulohumeral Muscular Dystrophy (FSHD) is in the top three list of all dystrophies with an approximate 1:8000 incidence. It is not a life-threatening disease; however, the progression of the disease extends over being wheelchair bound. Despite some drug trials continuing, including DUX4 inhibition, TGF-ß inhibition and resokine which promote healthier muscle, there is not an applicable treatment option for FSHD today. Still, there is a need for new agents to heal, stop or at least slow down muscle wasting. Current FSHD studies involving nutraceuticals as vitamin C, vitamin E, coenzyme Q10, zinc, selenium, and phytochemicals as curcumin or genistein, daidzein flavonoids provide promising treatment strategies. In this review, we present the clinical and molecular nature of FSHD and focus on nutraceuticals and phytochemicals that may alleviate FSHD. In the light of the association of impaired pathophysiological FSHD pathways with nutraceuticals and phytochemicals according to the literature, we present both studied and novel approaches that can contribute to FSHD treatment. |
| Databáze: | OpenAIRE |
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