The Mammalian Circadian Timing System: Synchronization of Peripheral Clocks
| Autor: | Camille Saini, Ueli Schibler, A. Liani, David M. Suter, Pascal Gos |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Cells Timing system Biology Models Biological Biochemistry Synchronization Body Temperature 03 medical and health sciences 0302 clinical medicine Circadian Clocks Internal medicine Genetics medicine Animals Circadian rhythm Molecular Biology 030304 developmental biology Mammals 0303 health sciences Suprachiasmatic nucleus Sleep in non-human animals Bacterial circadian rhythms Peripheral Endocrinology Signal transduction Neuroscience 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Cold Spring Harbor symposia on quantitative biology |
| ISSN: | 1943-4456 0091-7451 |
| DOI: | 10.1101/sqb.2011.76.010918 |
| Popis: | Mammalian physiology has to adapt to daily alternating periods during which animals either forage and feed or sleep and fast. The adaptation of physiology to these oscillations is controlled by a circadian timekeeping system, in which a master pacemaker in the suprachiasmatic nucleus (SCN) synchronizes slave clocks in peripheral organs. Because the temporal coordination of metabolism is a major purpose of clocks in many tissues, it is important that metabolic and circadian cycles are tightly coordinated. Recent studies have revealed a multitude of signaling components that possibly link metabolism to circadian gene expression. Owing to this redundancy, the implication of any single signaling pathway in the synchronization of peripheral oscillators cannot be assessed by determining the steady-state phase, but instead requires the monitoring of phase-shifting kinetics at a high temporal resolution. |
| Databáze: | OpenAIRE |
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