Cytotoxicity evaluation of a new radiopaque resin additive--triphenyl bismuth
| Autor: | M. V. Marshall, H. L. Cardenas, Israel Cabasso, Henry R Rawls, H. R. Bhagat |
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| Rok vydání: | 1992 |
| Předmět: |
Materials science
Biocompatibility Acrylic Resins chemistry.chemical_element Contrast Media Bismuth chemistry.chemical_compound Terphenyl Compounds Organometallic Compounds Humans General Materials Science Composite material Cytotoxicity General Dentistry Acrylic resin Lung Curing (chemistry) Aqueous solution technology industry and agriculture Fibroblasts Monomer chemistry Polymerization Mechanics of Materials Glass Ionomer Cements visual_art visual_art.visual_art_medium Silicate Cement Nuclear chemistry |
| Zdroj: | Dental materials : official publication of the Academy of Dental Materials. 8(1) |
| ISSN: | 0109-5641 |
| Popis: | Triphenyl bismuth (Ph 3 Bi) is a promising new additive for making biomedical resins visible on x-ray images. We evaluated the cytotoxicity of Ph 3 Bi, both alone and as a component of a denture resin, as an initial step in determining its biocompatibility. These experimental materials were compared with several types of dental materials that are in current clinical use (PMMA denture acrylic resin, two-photo-cured sealants, and two glass-ionomer cements). Human embryonic lung fibroblast tissue cultures (WI-38 cells) were exposed to 24-hour aqueous extracts of the materials. Changes in cell growth, cell viability, and the visual appearance of cells were used for the assessment of toxic response. Only a slight degree of cytotoxicity was observed for Ph 3 Bi, both alone and in combination with self-cured PMMA. All clinical materials showed a higher level of cytotoxicity than did Ph 3 Bi. The sealants and cements exhibited the most cytotoxicity and PMMA acrylic the least. The cytotoxicity of PMMA was elevated slightly by inclusion of Ph 3 Bi, probably due to decreased monomer conversion. When stored in water, the already low levels of cytotoxicity of both PMMA and PMMA with added Ph 3 Bi were reduced even further. From these results, we can predict a high level of safety for Ph 3 Bi as a radiopaque additive for biomedical resins. Any toxicity associated with Ph 3 Bi-containing resins can be reduced or avoided by prior extraction. Alternatively, curing conditions can be selected that would drive the polymerization reaction to a higher level of conversion. |
| Databáze: | OpenAIRE |
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