Medium-Chain Fatty Acids Released from Polymeric Electrospun Patches Inhibit Candida albicans Growth and Reduce the Biofilm Viability
| Autor: | Paul V. Hatton, Tahani M Binaljadm, Katharina H. Clitherow, Jens C. Hansen, Craig Murdoch, Sebastian G. Spain |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antifungal Agents
food.ingredient 0206 medical engineering Biomedical Engineering oral medicine 02 engineering and technology Drug resistance Article Microbiology Biomaterials food Candidiasis Oral Candida albicans medicine Humans Agar Oral mucosa electrospinning drug resistance biology Chemistry Fatty Acids technology industry and agriculture Biofilm 021001 nanoscience & nanotechnology biology.organism_classification candidiasis 020601 biomedical engineering Corpus albicans medicine.anatomical_structure Biofilms Drug delivery Toxicity 0210 nano-technology antifungal |
| Zdroj: | ACS Biomaterials Science & Engineering |
| ISSN: | 2373-9878 |
| DOI: | 10.1021/acsbiomaterials.0c00614 |
| Popis: | Oral candidiasis is a very common oral condition among susceptible individuals, with the main causative organism being the fungus Candida albicans. Current drug delivery systems to the oral mucosa are often ineffective because of short drug/tissue contact times as well as increased prevalence of drug-resistant Candida strains. We evaluated the potency of saturated fatty acids as antifungal agents and investigated their delivery by novel electrospun mucoadhesive oral patches using agar disk diffusion and biofilm assays. Octanoic (C8) and nonanoic (C9) acids were the most effective at inhibiting C. albicans growth on disk diffusion assays, both in solution or when released from polycaprolactone (PCL) or polyvinylpyrrolidone/RS100 (PVP/RS100) electrospun patches. In contrast, dodecanoic acid (C12) displayed the most potent antifungal activity against pre-existing C. albicans biofilms in solution or when released by PCL or PVP/RS100 patches. Both free and patch-released saturated fatty acids displayed a significant toxicity to wild-type and azole-resistant strains of C. albicans. These data not only provide evidence that certain saturated fatty acids have the potential to be used as antifungal agents but also demonstrate that this therapy could be delivered directly to Candida-infected sites using electrospun mucoadhesive patches, demonstrating a potential new therapeutic approach to treat oral thrush. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|