The effect of consumption temperature on the homeostatic and hedonic responses to glucose ingestion in the hypothalamus and the reward system
| Autor: | Annette A. van den Berg-Huysmans, Marco Hoeksma, Jeroen van der Grond, Anna M. van Opstal, Hanno Pijl, Serge A.R.B. Rombouts, Cor Blonk |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent ventral tegmental area Medicine (miscellaneous) Glucose ingestion Satiation Stimulus (physiology) Body Mass Index Young Adult 03 medical and health sciences Reward system 0302 clinical medicine Double-Blind Method Reward Internal medicine medicine Homeostasis Humans Insulin Ingestion Obesity hypothalamus glucose Cross-Over Studies Nutrition and Dietetics Chemistry temperature medicine.disease Magnetic Resonance Imaging Oxygen Ventral tegmental area 030104 developmental biology medicine.anatomical_structure Endocrinology nervous system reward system Hypothalamus Nutritive Sweeteners energy sensing 030217 neurology & neurosurgery |
| Zdroj: | American Journal of Clinical Nutrition, 107(1), 20-25 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/nqx023 |
| Popis: | Background Excessive consumption of sugar-sweetened beverages (SSBs) has been associated with obesity and related diseases. SSBs are often consumed cold, and both the energy content and temperature might influence the consumption behavior for SSBs. Objective The main aim of this study was to elucidate whether consumption temperature and energy (i.e., glucose) content modulate homeostatic (hypothalamus) and reward [ventral tegmental area (VTA)] responses. Design Sixteen healthy men participated in our study [aged 18-25 y; body mass index (kg/m2): 20-23]. High-resolution functional magnetic resonance imaging data were collected after ingestion of 4 different study stimuli: plain tap water at room temperature (22°C), plain tap water at 0°C, a glucose-containing beverage (75 g glucose dissolved in 300 mL water) at 22°C, and a similar glucose drink at 0°C. Blood oxygen level-dependent (BOLD) changes from baseline (7 min preingestion) were analyzed over time in the hypothalamus and VTA for individual stimulus effects and for effects between stimuli. Results In the hypothalamus, water at 22°C led to a significantly increased BOLD response; all other stimuli resulted in a direct, significant decrease in BOLD response compared with baseline. In the VTA, a significantly decreased BOLD response compared with baseline was found after the ingestion of stimuli containing glucose at 0°C and 22°C. These responses were not significantly modulated by consumption temperature. The consumption of plain water did not have a significant VTA BOLD effect. Conclusions Our data show that glucose at 22°C, glucose at 0°C, and water at 0°C lowered hypothalamic activity, which is associated with increased satiation. On the contrary, the consumption of water at room temperature increased activity. All stimuli led to a similar VTA response, which suggests that all drinks elicited a similar hedonic response. Our results indicate that, in addition to glucose, the low temperature at which SSBs are often consumed also leads to a response from the hypothalamus and might strengthen the response of the VTA. This trial was registered at www.clinicaltrials.gov as NCT03181217. |
| Databáze: | OpenAIRE |
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