The acid-sensing ion channel ASIC1a mediates striatal synapse remodeling and procedural motor learning
| Autor: | Di Shi Liu, Yi Zhi Wang, Zhe Yu, Michael X. Zhu, Ying Li, Xing Lei Song, Tian Le Xu, Yan Jiao Wu, Wei Guang Li, Siyu Zhang, Nan-Jie Xu, Qin Jiang |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Dendritic spine Motor Activity Medium spiny neuron Biochemistry Synaptic Transmission Article 03 medical and health sciences 0302 clinical medicine Postsynaptic potential Ca2+/calmodulin-dependent protein kinase Animals Learning Phosphorylation Molecular Biology Mice Knockout Neurons Chemistry Cell Biology Corpus Striatum Acid Sensing Ion Channels 030104 developmental biology nervous system Synaptic plasticity Synapses Excitatory postsynaptic potential NMDA receptor Motor learning Calcium-Calmodulin-Dependent Protein Kinase Type 2 Neuroscience 030217 neurology & neurosurgery |
| Popis: | Acid-sensing ion channel 1a (ASIC1a) is abundant in multiple brain regions, including the striatum, which serves as the input nucleus of the basal ganglia and is critically involved in procedural learning and motor memory. We investigated the functional role of ASIC1a in striatal neurons. We found that ASIC1a was critical for striatum-dependent motor coordination and procedural learning by regulating the synaptic plasticity of striatal medium spiny neurons. Global deletion of Asic1a in mice led to increased dendritic spine density but impaired spine morphology and postsynaptic architecture, which were accompanied by the decreased function of N-methyl-D-aspartate (NMDA) receptors at excitatory synapses. These structural and functional changes caused by the loss of ASIC1a were largely mediated by reduced activation (phosphorylation) of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and extracellular signal–regulated protein kinases (ERKs). Consequently, Asic1a null mice exhibited poor performance on multiple motor tasks, which was rescued by striatal-specific expression of either ASIC1a or CaMKII. Together, our data reveal a previously unknown mechanism mediated by ASIC1a that promotes the excitatory synaptic function underlying striatum-related procedural learning and memory. |
| Databáze: | OpenAIRE |
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