DIALYSIS FOR INTOXICATION WITH LIPID SOLUBLE DRUGS
| Autor: | James H. Shinaberger, Leroy Shear, Leo R. Goldbaum, Lloyd E. Clayton, Kevin G. Barry, Marjorie Knowlton |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Cottonseed Oil
medicine.medical_treatment Biomedical Engineering Biophysics Bioengineering Kidney Toxicology Peritoneal dialysis Biomaterials Dogs Renal Dialysis Dialysis Solutions medicine Humans Semipermeable membrane Solubility Chromatography Chemistry Research General Medicine Lipids Glutethimide Membrane Blood chemistry Fluid Therapy Emulsions lipids (amino acids peptides and proteins) Hemodialysis Dialysis (biochemistry) Dialysis Peritoneal Dialysis Kidneys Artificial medicine.drug |
| Zdroj: | ASAIO Journal. 11:173-177 |
| ISSN: | 1058-2916 |
| DOI: | 10.1097/00002480-196504000-00034 |
| Popis: | These in vivo studies demonstrate that the removal of glutethimide during dialysis is significantly increased when lipid is substituted for the usual aqueous dialysis solution. The very low water solubility of many lipid soluble compounds probably limits their removal by routine dialysis methods. Their high lipid solubility not only permits relatively small volumes of lipid dialysate to contain large amounts of these drugs, but also prevents back diffusion after they have crossed a semipermeable membrane from an aqueous into a lipid phase. This maintains a maximum effective diffusion gradient, resulting in an increased rate of net transfer across the membrane. Concentration ratios during peritoneal dialysis with lipid increased more rapidly than during hemodialysis. This suggests that glutethimide diffuses through the lipid-containing cells of the peritoneum more readily than it does through the cellulose dialyzer membrane. Peritoneal dialysis with lipid emulsion regularly produced visible lipemia which was associated with a slight increase in blood glutethimide concentration. This suggests that glutethimide was extracted from tissue depots into the lipemic plasma. The long-term effects of intraperitoneal lipid emulsion infusion have not been adequately studied, and clinical use of peritoneal dialysis with lipid must await further animal tolerance studies. (Author) |
| Databáze: | OpenAIRE |
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