Antibodies to extracellular matrix proteins in the sera of MRL-lpr mice
| Autor: | J. Tonzetich, Leslie G. Ratkay, J D Waterfield |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Immunology Arthritis Enzyme-Linked Immunosorbent Assay Cross Reactions Biology urologic and male genital diseases medicine.disease_cause Antibodies Autoimmune Diseases Pathology and Forensic Medicine Serology Autoimmunity Arthritis Rheumatoid Mice immune system diseases Laminin medicine Animals Lupus Erythematosus Systemic Immunology and Allergy Synovial fluid skin and connective tissue diseases Extracellular Matrix Proteins Autoantibody medicine.disease Fibronectins Fibronectin biology.protein Female Proteoglycans Collagen Antibody |
| Zdroj: | Clinical Immunology and Immunopathology. 59:236-245 |
| ISSN: | 0090-1229 |
| Popis: | Autoimmune MRL-lpr mice develop a spontaneous arthritis displaying similar articular and extra-articular features to rheumatoid arthritis in humans. In this study we used an ELISA assay to evaluate the serological responses of MRL-lpr mice to select extracellular matrix proteins associated with the joint. Significant levels of antibodies to collagens types I, II, III, IV, and V were demonstrated starting between 17 and 20 weeks of age. Moreover, the sera contained a strong reactivity to fibronectin. Responses to proteoglycans and laminin were weaker but still detectable. Specificity studies on pooled sera from MRL-lpr mice suggest that the autoantibodies produced are highly cross-reactive. The results indicate that the MRL-lpr mouse strain exhibits similar anti-extracellular matrix antibody profiles to those seen in varying frequencies in the sera and synovial fluid of patients with rheumatoid arthritis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|