Exploration of fluoroquinolone-induced retinal pigment epithelium layer changes in the pathogenesis of macular degeneration
| Autor: | Özçelik-Köse, Alev, Çekiç, Osman, Kaya, Cevdet |
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| Přispěvatelé: | Ozcelik-Kose A., ÇEKİÇ O., Kaya C., İstinye Üniversitesi, Hastane, Cevdet Kaya / 0000-0002-2424-1998, Kaya, Cevdet, Cevdet Kaya / AFN-7296-2022 |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Internal Diseases
Photostress recovery time H2O2 Biophysics Retinal Pigment Epithelium Dermatology Sağlık Bilimleri İç Hastalıkları Clinical Medicine (MED) Optic coherence tomography Phototoxicity Macular Degeneration Mice Fluoroquinolone ANTIBACTERIAL AGENT DOUBLE-ORGAN BIAS Health Sciences Animals Humans Pharmacology (medical) Klinik Tıp (MED) Contrast sensitivity Fluorescein Angiography ENROFLOXACIN Internal Medicine Sciences Klinik Tıp Retinal Degeneration Dahili Tıp Bilimleri CLINICAL MEDICINE ONCOLOGY Onkoloji Tıp CONTROLLED-TRIALS Photochemotherapy Acute retinal degeneration Medicine ONKOLOJİ Rabbits ANTIBIOTICS Tomography Optical Coherence Fluoroquinolones |
| ISSN: | 0008-6479 |
| Popis: | Purpose: Fluoroquinolone toxicity studies in animals (cats, rabbits and mice) showed that acute retinal degenerations appear clinically related to phototoxicity. The aim of this study was to evaluate the association between the administration of oral fluoroquinolone and the onset of clinically or subclinically detectable acute retinal degeneration at human. Material and methods: This study included patients that received oral fluoroquinolone treatment (ciprofloxacin, levofloxacin or moxifloxacin) for variable systemic diseases diagnosed by the Department of Urology and Infectious Diseases (study group, n=76), and age and sex matched otherwise healthy subjects (control group, n=50). All the subjects underwent a detailed ophthalmologic examination including tests for visual acuity, intraocular pressures, color vision, photostress recovery time and contrast sensitivity measurements, central foveal thickness, subfoveal choroidal thickness, ganglion cell complex thickness and 10/2 Humphrey visual field test. Color fundus and fundus autofluorescence photographs were also obtained. Examinations and tests were repeated at 1st week and 1st month in the study group. Results: There was no statistically significant difference among visual acuity, intraocular pressure, photostress recovery time, color vision, contrast sensitivity measurements, central foveal thickness, subfoveal choroidal thickness, average ganglion cell complex thickness, superior ganglion cell complex thickness, inferior ganglion cell complex thickness, focal loss volume, global loss volume, mean deviation, pattern standard deviation values in treatment group at baseline, 1st week and 1st month (p > 0.05, for the comparison of each parameters). There was not any alteration among color fundus and fundus autofluorescence photographs obtained at baseline, 1st week and 1st month in treatment group. All parameters within the study and control groups were similar throughout the study period (p > 0.05, for the comparison of each parameter). Conclusion: This study is the first prospective clinical study that evaluated the association between the administration of oral fluoroquinolone and the onset of acute retinal degeneration. Preliminary results of this study showed that use of oral fluoroquinolone had no detectable impact on retinal degeneration at acute phase. Keywords: acute retinal degeneration; contrast sensitivity; fluoroquinolone; optic coherence tomography; photostress recovery time; phototoxicity. WOS:000864792600005 35820634 Q3 |
| Databáze: | OpenAIRE |
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