Aging signaling pathways and circadian clock-dependent metabolic derangements
| Autor: | Maria Florencia Tevy, Zachary Pincus, Manlio Vinciguerra, Gianluigi Mazzoccoli, Jadwiga M. Giebultowicz |
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| Rok vydání: | 2013 |
| Předmět: |
Aging
medicine.medical_specialty Endocrinology Diabetes and Metabolism media_common.quotation_subject Longevity ved/biology.organism_classification_rank.species Circadian clock Carbohydrate metabolism Biology Article Endocrinology Metabolic Diseases Species Specificity Circadian Clocks Internal medicine medicine Animals Humans Circadian rhythm Model organism Organism Tissue homeostasis Caloric Restriction media_common Suprachiasmatic nucleus ved/biology Feeding Behavior Diet Disease Models Animal Energy Metabolism Neuroscience Signal Transduction |
| Zdroj: | Trends in Endocrinology & Metabolism. 24:229-237 |
| ISSN: | 1043-2760 |
| DOI: | 10.1016/j.tem.2012.12.002 |
| Popis: | The circadian clock machinery orchestrates organism metabolism in order to ensure that development, survival and reproduction are attuned to diurnal environmental variations. For unknown reasons, there is a decline in circadian rhythms with age, concomitant with declines in the overall metabolic tissues homeostasis and changes in the feeding behavior of aged organisms. This disruption of the relationship between the clock and the nutrient sensing networks might underlie age-related diseases; overall, greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed. In this review we address the complex links between the circadian clock, metabolic (dys)functions and aging in different model organisms. |
| Databáze: | OpenAIRE |
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