A general synthesis of arylindoles and (1-arylvinyl)carbazoles via a one-pot reaction from N-tosylhydrazones and 2-nitro-haloarenes and their potential application to colon cancer

Autor:	Ali Hachem, Mouad Alami, Timothée Naret, Jérôme Bignon, Ali Khalaf, Tourin Bzeih, Abdallah Hamze, Nada Jaber, Jean-Daniel Brion
Rok vydání:	2016
Předmět:	Indoles Colorectal cancer Carbazoles Tumor cells 010402 general chemistry Hydrocarbons Aromatic 01 natural sciences Catalysis Tosyl Compounds Tumor Cells Cultured Materials Chemistry medicine Humans Molecule Molecular Structure 010405 organic chemistry Chemistry Hydrazones Metals and Alloys Colon cancer cell General Chemistry Nitro Compounds medicine.disease Combinatorial chemistry 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Cyclization One pot reaction Colonic Neoplasms Ceramics and Composites Nitro
Zdroj:	Chemical Communications. 52:13027-13030
ISSN:	1364-548X 1359-7345
DOI:	10.1039/c6cc07666a
Popis:	A convergent and effective synthesis of 3-aryl-indoles, 2,3-diaryl indoles, and (1-arylvinyl)carbazoles from a one-pot sequence involving the coupling of N-tosylhydrazones with ortho-nitro-haloarenes followed by a cyclization has been developed. Compound 5i exhibits excellent antiproliferative activity in the low nM range against colon cancer cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a511d7eed3afab2188495940a1dfe75 https://doi.org/10.1039/c6cc07666a Zobrazit plný text záznamu