Treatment outcomes and relapses of pulmonary tuberculosis in Lazio, Italy, 1999-2001: a six-year follow-up study
| Autor: | 2. A. Faustini, A. J. Hall, J. Mantovani, M. Sangalli, C. A. Perucci, M, Ciardi, G, Iaiani, C. Mastroianni, C. Mastropietro, A. Teggi, R. Cauda, A. Cingolani, S. Di Giambenedetto, C. Saltini, M. De Marco, P. Ghirba, S. Grisetti, F. Palmieri, A. Rianda, M. Traversa, M. Alma, F. Antonelli, G. Pugliesi, M. Olivieri, A. Rossi, M. Sanguinetti, I. Simeoni, A. Pandolfi, E. Bologna, M. Carrescia, P. Alimenti, M. Cantero, F. Ticca, L. Lancella, D. Dainotto, S. Geraci, E. Anzalone, A. R. Buratti, R. Zanini, A. Signore, S. M. Goretti, G. Munafò, F. Autore, A. Pitorri, R. Le Donne, A. Armignaco, G. Bernardini, C. M. Fiorani, L. Di Michele, F. De Padova, M. Manenti, G. Runci, P. Rossi, S. Aquilani, R. Cecere, A. Ercole, G. Esterini, L. Gallo, C. Gnesivo, R. Guadagnali, V. Labriola, M. R. Loffredo, P. Pasqualitto, P. Patti, P. Porcelli, E. Tanzariello, BOCCHINO, MARIALUISA |
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| Přispěvatelé: | 2. A., Faustini, A. J., Hall, J., Mantovani, M., Sangalli, C. A., Perucci, M, Ciardi, G, Iaiani, C., Mastroianni, C., Mastropietro, A., Teggi, R., Cauda, A., Cingolani, S., Di Giambenedetto, C., Saltini, Bocchino, Marialuisa, M., De Marco, P., Ghirba, S., Grisetti, F., Palmieri, A., Rianda, M., Traversa, M., Alma, F., Antonelli, G., Pugliesi, M., Olivieri, A., Rossi, M., Sanguinetti, I., Simeoni, A., Pandolfi, E., Bologna, M., Carrescia, P., Alimenti, M., Cantero, F., Ticca, L., Lancella, D., Dainotto, S., Geraci, E., Anzalone, A. R., Buratti, R., Zanini, A., Signore, S. M., Goretti, G., Munafò, F., Autore, A., Pitorri, R., Le Donne, A., Armignaco, G., Bernardini, C. M., Fiorani, L., Di Michele, F., De Padova, M., Manenti, G., Runci, P., Rossi, S., Aquilani, R., Cecere, A., Ercole, G., Esterini, L., Gallo, C., Gnesivo, R., Guadagnali, V., Labriola, M. R., Loffredo, P., Pasqualitto, P., Patti, P., Porcelli, E., Tanzariello |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Tuberculosis Adolescent Medical record-linkage Population Antitubercular Agents Drug resistance Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA Young Adult TB relapses Foreign born Recurrence Internal medicine medicine Humans Treatment Failure Risk factor Young adult education Tuberculosis Pulmonary Aged education.field_of_study Unsuccessful TB treatment business.industry Medical record Respiratory disease General Medicine Middle Aged TB treatment outcomes Prognosis medicine.disease Surgery Treatment Outcome Infectious Diseases Italy Risk factors Female business Follow-Up Studies |
| Popis: | Summary Objectives The aim of this study was to enhance tuberculosis (TB) treatment outcome monitoring by linking diverse surveillance systems and estimating treatment outcomes including relapse. Methods Tuberculosis treatment was surveyed in the Lazio region (Italy) from 1999 to 2001; a six-year follow-up of notified cases was undertaken to detect relapses. The results were analyzed as a population-based case–control study comparing each unsuccessful outcome and relapse with eligible controls. Results Of the 974 patients who entered the survey, 805 (82.6%) had complete treatment evaluations; 398 (49.4%) had a successful outcome, 401 (49.8%) had an unsuccessful outcome, and six developed chronic TB. Death was associated with age >64 years (OR 5.9; 95% CI 3.1–11.2), male gender (OR 2.1; 95% CI 1.0–4.4), and using second-line drugs (OR 2.3; 95% CI 1.0–5.4). Treatment failure was associated with previous treatment (OR 3.0; 95% CI 1.4–6.7) and being male, being foreign born (OR 6.6; 95% CI 2.1–21.2), receiving second-line drugs (OR 7.4; 95% CI 1.8–29.5), and receiving modified therapy (OR 5.1; 95% CI 1.7–14.9). Relapses after successful outcomes were detected in 5.5%, for which the strongest predictor was having extrapulmonary lesions (OR 22.8; 95% CI 1.8–287.3). Conclusions Linking our survey data to other surveillance systems improved the mortality estimates and detected a high rate of relapse. Having received previous treatment and being a foreigner were independent determinants of treatment failure, suggesting that both acquired and primary drug resistance affect TB patients in Lazio. |
| Databáze: | OpenAIRE |
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