Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer: A phase. study
| Autor: | Rasul Sharifov, Serap Yucel, Esra Kaytan-Saglam, Cetin Ordu, Oktar Asoglu, Zeynep Güral, Semen Onder, Hediye Acun, Sezer Saglam, Ethem Nezih Oral, Ahmet Kizir |
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| Přispěvatelé: | Acibadem University Dspace, SHARIFOV, RASUL |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
business.industry Colorectal cancer Gastroenterology Urology Locally advanced Phases of clinical research Clinical Practice Study 030230 surgery medicine.disease A phase II study.- World journal of gastrointestinal oncology cilt.10 ss.40-47 2018 [Gural Z. Saglam S. Yucel S. Kaytan-Saglam E. Asoglu O. Ordu C. Acun H. Sharifov R. Onder S. Kizir A. et al. -Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer] Neoadjuvant chemoradiotherapy 03 medical and health sciences 0302 clinical medicine Oncology Fluorouracil 030220 oncology & carcinogenesis Concomitant Medicine Rectal cancer business Hyperfractionated accelerated radiotherapy medicine.drug |
| Zdroj: | World Journal of Gastrointestinal Oncology |
| Popis: | AIM To evaluate the efficacy and tolerability of neoadjuvant hyperfractionated accelerated radiotherapy (HART) and concurrent chemotherapy in patients with locally advanced infraperitoneal rectal cancer. METHODS A total of 30 patients with histopathologically confirmed T2-3/N0+ infraperitoneal adenocarcinoma of rectum cancer patients received preoperative 42 Gy/1.5 Gy/18 days/bid radiotherapy and continuous infusion of 5-fluorouracil (325 mg/m(2)). All patients were operated 4-8 wk after neoadjuvant concomitant therapy. RESULTS In the early phase of treatment, 6 patients had grade III- IV gastrointestinal toxicity, 2 patients had grade III-IV hematologic toxicity, and 1 patient had grade V toxicity due to postoperative sepsis during chemotherapy. Only 1 patient had radiotherapy-related late side effects, i.e., grade IV tenesmus. Complete pathological response was achieved in 6 patients (21\%), while near-complete pathological response was obtained in 9 (31\%). After a median follow-up period of 60 mo, the local tumor control rate was 96.6\%. In 13 patients, distant metastasis occurred. Disease-free survival rates at 2 and 5 years were 63.3\% and 53\%, and corresponding overall survival rates were 70\% and 53.1\%, respectively. CONCLUSION Although it has excellent local control and complete pathological response rates, neoadjuvant HART concurrent chemotherapy appears to not be a feasible treatment regimen in locally advanced rectal cancer, having high perioperative complication and intolerable side effects. Effects of reduced 5-fluorouracil dose or omission of chemotherapy with the aim of reducing toxicity may be examined in further studies. |
| Databáze: | OpenAIRE |
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