Effects of Dietary Sodium and Magnesium on Cyclosporin A–Induced Hypertension and Nephrotoxicity in Spontaneously Hypertensive Rats
| Autor: | Anna-Kaisa Pere, Terttu-Liisa Teräväinen, Juhani Ahonen, Heikki Karppanen, Eero Mervaala, Kirsi Karjala, Heikki Vapaatalo, Leena Lindgren, Juha Laakso |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty chemistry.chemical_element Blood Pressure 030204 cardiovascular system & hematology Calcium Nephrotoxicity Excretion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rats Inbred SHR Cyclosporin a Internal medicine Internal Medicine medicine Animals Drug Interactions Magnesium 030304 developmental biology 2. Zero hunger 0303 health sciences Creatinine Kidney Dose-Response Relationship Drug business.industry Sodium Dietary Rats 3. Good health Endocrinology medicine.anatomical_structure Blood pressure chemistry Hypertension Cyclosporine Kidney Diseases business Immunosuppressive Agents |
| Zdroj: | Hypertension. 29:822-827 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.29.3.822 |
| Popis: | Arterial hypertension, nephrotoxicity, and magnesium loss are common side effects of the immunosuppressive agent cyclosporin A (CsA). In the present study, the effects of dietary sodium and magnesium on CsA toxicity were examined in spontaneously hypertensive rats. A 6-week treatment with CsA during a moderately low-sodium diet (Na 0.3%, Mg 0.2% of the dry weight of the chow) raised blood pressure only slightly, without evidence of nephrotoxicity. By contrast, CsA during a high-sodium diet (Na 2.6%) produced a pronounced rise in blood pressure as well as marked nephrotoxicity, comprising decreased creatinine clearance, increased levels of serum creatinine and urea, and increased urinary protein excretion. During the high-sodium diet, CsA decreased myocardial and bone magnesium concentration and increased myocardial and renal calcium concentration. Magnesium supplementation (Mg 0.6%) protected against the CsA-induced hypertension and nephrotoxicity during the high-sodium diet. Magnesium supplementation also completely prevented the CsA-induced myocardial magnesium depletion and calcium accumulation in the heart and kidney during the high-sodium diet. Our findings indicate a detrimental interaction between increased sodium intake and CsA treatment and a marked protection by concomitant oral magnesium supplementation. |
| Databáze: | OpenAIRE |
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