Exercise training causes a partial improvement through increasing testosterone and eNOS for erectile function in middle-aged rats
| Autor: | Byoung Doo Rhee, Yeon Hee Noh, Dae Yun Seo, Sung Ryul Lee, Kyung Soo Ko, Kyo Won Seo, Hyo-Bum Kwak, Jin Han, Kang-Moon Song, H. Park, Ji-Kan Ryu |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Aging medicine.medical_specialty Nitric Oxide Synthase Type III 030209 endocrinology & metabolism Biochemistry Rats Sprague-Dawley Random Allocation 03 medical and health sciences 0302 clinical medicine Endocrinology Sex hormone-binding globulin Erectile Dysfunction Enos Physical Conditioning Animal Physical Stimulation Internal medicine Pressure Genetics medicine Animals Testosterone Increased serum testosterone level Endothelial dysfunction Molecular Biology biology business.industry Penile Erection Cell Biology medicine.disease biology.organism_classification Actins Prolactin Rats 030104 developmental biology Erectile dysfunction biology.protein Luteinizing hormone business Penis |
| Zdroj: | Experimental Gerontology. 108:131-138 |
| ISSN: | 0531-5565 |
| Popis: | Purpose Aging changes the balance of sex hormones and causes endothelial dysfunction in the penis, both of which are important determinants of erectile dysfunction (ED). The purpose of this study was to evaluate whether exercise training could protect against erectile dysfunction by increasing serum testosterone and penile eNOS levels in aging rats. Methods A total of 14 young (2-month-old) and 14 middle-aged (18-month-old) Sprague Dawley rats were randomly assigned to either untrained control (young control, [YC], middle-aged control, [MC]) or endurance exercise-trained (young exercise, [YE], middle-aged exercise, [ME]) groups with seven rats per group. The exercise groups trained with treadmill running for 6 weeks. Body composition parameters (body weight, heart mass, liver mass, and testicular mass), serum sex hormone levels (testosterone, luteinizing hormone, follicle-stimulating hormone, and prolactin), endothelial function-related parameters in the penis (endothelial nitric oxide synthase [eNOS], CD31, alpha smooth muscle actin [α-SMA]), and maximal intracavernous pressure measure (ICP) and total ICP were analyzed in middle-aged rats. Results The middle-aged groups showed increased body weight, as compared with the young groups, but exercise training attenuated the aging-induced increase in body weight. The middle-aged groups had lower testicular mass compared with the young groups, but exercise training attenuated aging-induced decreases in testicular mass. Exercise training increased serum testosterone levels in both the young and middle-aged groups. However, there were no changes in the levels of luteinizing hormone, follicle-stimulating hormone, and prolactin among the groups. MC group showed decreased protein levels of p-eNOS, as compared with the YC group. However, exercise training protected against aging-induced decrease in eNOS and p-eNOS protein levels in the penis. Interestingly, exercise training also increased protein levels of α-SMA and maximal ICP in the middle-aged group. Conclusions Exercise training has beneficial effects on erectile function in aged rats through increased testosterone production from the testis and strengthening of the cavernous endothelium with activation of eNOS. Therefore, exercise training may be a therapeutic modality for improving erectile dysfunction associated with aging. |
| Databáze: | OpenAIRE |
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