The polymorphism −1131T>C in apolipoprotein A5 gene is associated with dyslipidemia in Brazilian subjects
| Autor: | Maria da Gloria Carvalho, Cristina R. Almeida, Andréia Assis Loures-Vale, Izabela R. Santos, Marinez O. Sousa, Ana Paula Fernandes, Kathryna Fontana Rodrigues, Ângela Maria Quintão Lana, Cláudia N. Ferreira, Karina Braga Gomes |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Apolipoprotein B Polymorphism Single Nucleotide chemistry.chemical_compound Gene Frequency Risk Factors Polymorphism (computer science) Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Allele frequency Alleles Apolipoproteins A Triglycerides Dyslipidemias biology Cholesterol Case-control study General Medicine Middle Aged medicine.disease Minor allele frequency Logistic Models Endocrinology chemistry Apolipoprotein A-V Cardiovascular Diseases Case-Control Studies Multivariate Analysis biology.protein Female Brazil Dyslipidemia |
| Zdroj: | Gene. 516:171-175 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/j.gene.2012.12.016 |
| Popis: | Background Polymorphisms in apolipoprotein A5 gene (APOA5) have been associated with higher triglyceride levels in many populations. The aim of the study was to determine the allelic and genotypic distribution of the APOA5 − 1131T > C polymorphism and to identify the association of the genetic variant and the risk for dyslipidemia. Methods We genotyped 109 dyslipidemic subjects and 107 controls. The total cholesterol, triglycerides and HDL-c were determined enzymatically. Comparison of means among groups was calculated by ANOVA. Significant differences among groups were evaluated by Student–Newman–Keuls test. Results The minor allele C was more frequent in dyslipidemic subjects than controls ( p = 0.019) and confers an increased individual risk for dyslipidemia (OR = 1.726, CI 95% = 1.095–2.721). The genotype analysis by gender showed that this allele was more frequent in dyslipidemic males ( p = 0.037; OR = 2.050, CI 95% = 1.042–4.023). When participants were analyzed according to genotypes TT and TC/CC, C-carriers presented higher cholesterol and triglycerides levels than TT homozygous ( p = 0.046 and 0.049, respectively). Conclusions The allele C confers higher total cholesterol and triglycerides levels in dyslipidemic adults. The APOA5 − 1131T > C polymorphism is associated with dyslipidemia in male subjects. |
| Databáze: | OpenAIRE |
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