Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn
| Autor: | Julie A. Wixey, S. T. Bjorkman, Lara Jones, Seen-Ling Sim, Jatin Patel, Paul B. Colditz, Jane Sun, Kirat K. Chand, Elliot Teo, Kiarash Khosrotehrani, Stephanie M. Miller |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Day of life
Biomedical Engineering Medicine (miscellaneous) Inflammation Foetal brain Stem cells Neuroprotection Article Term placenta 03 medical and health sciences 0302 clinical medicine Foetal growth Medicine Neuroinflammation 030304 developmental biology 0303 health sciences business.industry Mesenchymal stem cell Development of the nervous system Cell Biology 3. Good health Cancer research medicine.symptom business 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-15 (2021) NPJ Regenerative Medicine |
| ISSN: | 2057-3995 |
| Popis: | The foetal brain is particularly vulnerable to the detrimental effects of foetal growth restriction (FGR) with subsequent abnormal neurodevelopment being common. There are no current treatments to protect the FGR newborn from lifelong neurological disorders. This study examines whether pure foetal mesenchymal stromal cells (MSC) and endothelial colony-forming cells (ECFC) from the human term placenta are neuroprotective through modulating neuroinflammation and supporting the brain vasculature. We determined that one dose of combined MSC-ECFCs (cECFC; 106 ECFC 106 MSC) on the first day of life to the newborn FGR piglet improved damaged vasculature, restored the neurovascular unit, reduced brain inflammation and improved adverse neuronal and white matter changes present in the FGR newborn piglet brain. These findings could not be reproduced using MSCs alone. These results demonstrate cECFC treatment exerts beneficial effects on multiple cellular components in the FGR brain and may act as a neuroprotectant. |
| Databáze: | OpenAIRE |
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