Transabdominal electrical stimulation increases colonic propagating pressure waves in paediatric slow transit constipation
| Autor: | Val J. Robertson, Anthony G. Catto-Smith, Janet Chase, Phil G. Dinning, Ian J. Cook, John M. Hutson, Di Simpson, Sebastian K. King, Melanie C.C. Clarke, Susan Gibb, Bridget R. Southwell |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Time Factors Constipation Adolescent Manometry Electric Stimulation Therapy Stimulation Risk Assessment Severity of Illness Index Reference Values Humans Medicine Slow transit constipation Child Gastrointestinal Transit Myoelectric Complex Migrating business.industry Australia Transcutaneous Electrical Stimulation General Medicine Intensity (physics) Surgery Treatment Outcome medicine.anatomical_structure Anesthesia Chronic Disease Pediatrics Perinatology and Child Health Interferential current Defecation Abdomen Female medicine.symptom Gastrointestinal Motility business Follow-Up Studies |
| Zdroj: | Journal of Pediatric Surgery. 47:2279-2284 |
| ISSN: | 0022-3468 |
| DOI: | 10.1016/j.jpedsurg.2012.09.021 |
| Popis: | In slow-transit constipation (STC) pancolonic manometry shows significantly reduced antegrade propagating sequences (PS) and no response to physiological stimuli. This study aimed to determine whether transcutaneous electrical stimulation using interferential current (IFC) applied to the abdomen increased colonic PS in STC children.Eight children (8-18 years) with confirmed STC had 24-h colonic manometry using a water-perfused, 8-channel catheter with 7.5 cm sidehole distance introduced via appendix stomas. They then received 12 sessions (20 min/3× per week) of IFC stimulation (2 paraspinal and 2 abdominal electrodes), applied at a comfortable intensity (40 mA, carrier frequency 4 kHz, varying beat frequency 80-150 Hz). Colonic manometry was repeated 2 (n=6) and 7 (n=2) months after IFC.IFC significantly increased frequency of total PS/24h (mean ± SEM, pre 78 ± 34 vs post 210 ± 62, p=0.008, n=7), antegrade PS/24h (43 ± 16 vs 112 ± 20, p=0.01) and high amplitude PS (HAPS/24h, 5 ± 2:10 ± 3, p=0.04), with amplitude, velocity, or propagating distance unchanged. There was increased activity on waking and 4/8 ceased using antegrade continence enemas.Transcutaneous IFC increased colonic PS frequency in STC children with effects lasting 2-7 months. IFC may provide a treatment for children with treatment-resistant STC. |
| Databáze: | OpenAIRE |
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