A comparative study of IL‐6, CRP and NT‐proBNP levels in post‐COVID multisystem inflammatory syndrome in children (MISC) and Kawasaki disease patients
| Autor: | Surupa Basu, Subhajit Dey Sarkar, Paramita Banerjee, Priyankar Pal, Alolika Nandi, Purbasha Gupta, Mimi Ganguly |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
MISC medicine.drug_class interleukin 6 India Mucocutaneous Lymph Node Syndrome NT‐proBNP Gastroenterology Child health Rheumatology Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Child Interleukin 6 PIMS Kawasaki disease biology Receiver operating characteristic Interleukin-6 SARS-CoV-2 business.industry C-reactive protein Curve analysis COVID-19 Infant Original Articles medicine.disease Peptide Fragments Systemic Inflammatory Response Syndrome C‐reactive protein C-Reactive Protein ROC Curve Child Preschool biology.protein Mann–Whitney U test Original Article business Biomarkers |
| Zdroj: | International Journal of Rheumatic Diseases |
| ISSN: | 1756-185X 1756-1841 |
| DOI: | 10.1111/1756-185x.14236 |
| Popis: | Background Post‐COVID multisystem hyperinflammatory syndrome in children (MISC) has clinical and laboratory similarities with Kawasaki disease (KD). Inflammatory markers like C‐reactive protein (CRP), interleukin 6 (IL6) as well as N‐terminal probrain natriuretic peptide (NT‐proBNP) are elevated in both. This study attempts a comparative analysis of the 3 markers in an attempt at early differentiation for planning appropriate management. Methodology This analytical study conducted at the Institute of Child Health, Kolkata, India compared the levels of the above 3 markers at admission between 72 patients with KD, 30% of whom had coronary artery lesions (CALs) collected over a period of 18 months (Jan 2017‐June 2018), with 71 MISC patients over a period of 6 months (July 2020‐December 2020). The non‐parametric Mann‐Whitney U test was used to test for similarity in distributions of the samples of CRP, NT‐proBNP and IL6 in KD and MISC patients using correction factor for similar ranks. The 3 parameters were compared using receiver operating characteristic (ROC) curve analysis. Results Mean IL6 value in KD was 83.22 pg/mL and in MISC 199.91 pg/mL, which was not found to be statistically significant (P = .322 > .05).However mean NT‐proBNP (914.91 pg/mL) with CRP level (96.32 mg/L) in KD was significantly lower (P 935.7 pg/mL and >99.55 mg/L respectively might act as a guide to differentiate between them. |
| Databáze: | OpenAIRE |
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