Epithelial‐to‐mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy
Autor: | Jiunn Liang Tan, Chong-Kin Liam, Mau Ern Poh, Chee Shee Chai, Ka Kiat Chin, Thian Chee Loh, Kein Seong Mun, Chee Kuan Wong |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine sarcoma Adenosquamous carcinoma Case Report Case Reports epithelial‐to‐mesenchymal transition lcsh:RC254-282 Metastasis 03 medical and health sciences 0302 clinical medicine Circulating tumor cell medicine Epithelial–mesenchymal transition Lung cancer business.industry General Medicine medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens adjuvant chemotherapy lung cancer 030104 developmental biology Oncology Adenosquamous lung carcinoma 030220 oncology & carcinogenesis Cancer research Sarcoma business Chemoradiotherapy |
Zdroj: | Thoracic Cancer, Vol 10, Iss 9, Pp 1841-1845 (2019) Thoracic Cancer |
ISSN: | 1759-7706 1759-7714 |
Popis: | Adjuvant chemotherapy has long been indicated to extend survival in completely resected stage IB to IIIA non-small cell lung cancer (NSCLC). However, there is accumulating evidence that chemotherapy or chemoradiotherapy can induce epithelial-to-mesenchymal transition (EMT) in disseminated or circulating NSCLC cells. Here, we describe the first case of EMT as the cause of recurrence and metastasis in a patient with resected stage IIB lung adenosquamous carcinoma after adjuvant chemotherapy. We review the literature and explore the possible mechanisms by which EMT occurs in disseminated tumor cells (DTC) or circulating tumor cells (CTC) in response to adjuvant chemotherapy (cisplatin) as a stressor. We also explore the possible therapeutic strategies to reverse EMT in patients with recurrence. In summary, although adjuvant cisplatin-based chemotherapy in resected NSCLC does extend survival, it may lead to the adverse phenomenon of EMT in disseminated tumor cells (DTC) or circulating tumor cells (CTC) causing recurrence and metastasis. |
Databáze: | OpenAIRE |
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