Gestational diabetes status and dietary intake modify maternal and cord blood allostatic load markers
Autor: | Lawrence Fordjour, Shuli Zou, Lori Hoepner, Ikhtiyor Djuraev, Chauntelle Jack-Roberts, Betul Kalkan, Patricia Maples, Wen-Ching Lee, Ella Gilboa, John G. Kral, Kaydine Edwards, Xinyin Jiang, Mudar Dalloul |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
endocrine system diseases
Endocrinology Diabetes and Metabolism Population Physiology Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences Eating 0302 clinical medicine nutrients Pregnancy Diabetes mellitus Glycemic load Medicine Humans 030212 general & internal medicine education education.field_of_study Fetus 030219 obstetrics & reproductive medicine diabetes business.industry nutritional and metabolic diseases RC648-665 medicine.disease Fetal Blood Allostatic load female genital diseases and pregnancy complications Gestational diabetes Diabetes Gestational Allostasis Cord blood Gestation Female Clinical care/Education/Nutrition business gestational diet Biomarkers |
Zdroj: | BMJ Open Diabetes Research & Care BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020) |
ISSN: | 2052-4897 |
Popis: | IntroductionAllostatic load (AL) defines cardiometabolic, inflammatory, and neuroendocrine changes in the body in response to internal and external stressors. It is largely unknown whether gestational diabetes mellitus (GDM) alters maternal and fetal AL, which in turn affects GDM outcomes. Whether dietary intakes and quality can modify AL and thus influence GDM progression is also unknown.Research design and methodsIn this study, we recruited 35 GDM and 30 non-GDM women in gestational week 25–33. Fasting blood samples were collected at enrollment, and cord venous blood samples were collected at delivery for the measurement of a series of AL biomarkers to calculate the composite AL index. Three-day dietary recalls were conducted at enrollment.ResultsResults suggest that GDM women had 60% higher composite AL index scores (p value=0.01). Maternal AL index was associated with shorter duration of gestation (β=−0.33, p value=0.047) and higher fetal AL index (β=0.47, p value=0.006) after adjusting for GDM status. Dietary intake of monounsaturated fatty acids was negatively associated with maternal AL index (β=−0.20, p value=0.006). GDM women had lower total caloric intake and dietary glycemic load, yet their linolenic acid, vitamin C and E intakes were also decreased (all p valueConclusionsIn this study, GDM status and dietary intakes modify AL in this population. AL may serve as an indicator of GDM control. Future research on dietary interventions that can improve maternal AL markers during GDM is warranted. |
Databáze: | OpenAIRE |
Externí odkaz: |