Characteristic expression of cell adhesion molecules in adhalin deficiency
| Autor: | Masanori Nakagawa, Masaru Inose, Naohito Niiyama, Hidetoshi Fukunaga, Kimiyoshi Arimura, Takahashi Goto, Fukuo Motokura, Mitsuhiro Osame, Itsuro Higuchi, Ryuichi Ohkubo, Khotaro Izumi |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Biopsy Cell Adhesion Molecules Neuronal Muscle Fibers Skeletal Intercellular Adhesion Molecule-1 Muscular Dystrophies Extracellular matrix Laminin Sarcoglycans medicine Humans Myocyte Muscular dystrophy Muscle Skeletal Extracellular Matrix Proteins Membrane Glycoproteins biology Cell adhesion molecule CD44 Middle Aged medicine.disease Immunohistochemistry Molecular biology Cytoskeletal Proteins Hyaluronan Receptors Neurology Immunology biology.protein Female Neural cell adhesion molecule Neurology (clinical) |
| Zdroj: | Journal of the Neurological Sciences. 143:79-83 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/s0022-510x(96)00139-6 |
| Popis: | We have reported the reduction of the B1 subunit of laminin and that of heparan sulfate proteoglycan (HSPG) in two Japanese patients with adhalin deficiency. We here investigated immunohistochemically the expression of cell adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1), neural cell adhesion molecule (NCAM), and CD44 (HCAM), in four Japanese patients with adhalin deficiency, compared to other types of muscular dystrophy. We found that NCAM was upregulated in a fair number of muscle fibers, regardless of the type of muscular dystrophy. ICAM-1 was detected on the rare muscle cell membrane in all patients. CD44 was barely detected on the muscle cell membrane in adhalin deficiency, in contrast to the strong expression of CD44 which was observed in other types of muscular dystrophy. These findings suggest that a different degenerative or regenerative process is involved in adhalin deficiency compared to other types of muscular dystrophy. |
| Databáze: | OpenAIRE |
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