Antinauseant and antiemetic properties of bismuth subsalicylate in dogs and humans
| Autor: | Marvin M. Goldenberg, Charles S. Davis, Leroy J. Honkomp |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male medicine.drug_class Nausea Vomiting Pharmaceutical Science Placebo Bismuth subsalicylate Placebos Dogs medicine Antiemetic Animals Humans Clinical Trials as Topic Dose-Response Relationship Drug business.industry food and beverages Ipecac Syrup Anesthesia Antiemetics Female medicine.symptom business Bismuth medicine.drug |
| Zdroj: | Journal of pharmaceutical sciences. 65(9) |
| ISSN: | 0022-3549 |
| Popis: | Laboratory and clinical investigations were carried out to determine the effectiveness of bismuth subsalicylate in allaying nausea by preventing the physical symptom of emesis. In normal conscious dogs, a bismuth subsalicylate formulation caused a dose‐related reduction in the incidence of vomiting in response to an emetic dose of ipecac syrup. In normal human subjects, a bismuth subsalicylate suspension, unlike the placebo formulation, successfully subdued nausea and vomiting in 66.7 and 80% of the subjects, respectively, in response to ipecac syrup. Both findings demonstrate that bismuth subsalicylate can provide antiemetic action and that the decrease in the occurrence of emesis in humans and dogs parallels the decrease in nausea found in humans and the nausea suspected to occur prior to emesis in dogs. |
| Databáze: | OpenAIRE |
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