Publisher Correction: Nasal mucus glutathione transferase activity and impact on olfactory perception and neonatal behavior
| Autor: | Jean-Marie Heydel, Philippe Faure, Aline Robert-Hazotte, Gérard Coureaud, Yves Artur, Fabrice Neiers, Catherine Potin |
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| Přispěvatelé: | Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ProdInra, Migration, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), Coureaud, Gérard, Heydel, Jean-Marie |
| Rok vydání: | 2019 |
| Předmět: |
Proteomics
Olfactory perception [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] lcsh:Medicine Physiology Receptors Odorant Pheromones 03 medical and health sciences 0302 clinical medicine Olfactory Mucosa Nasal mucus [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Food and Nutrition Animals Medicine [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Glutathione transferase activity lcsh:Science Physiologie Glutathione Transferase 030304 developmental biology 0303 health sciences Multidisciplinary business.industry lcsh:R Neurosciences Feeding Behavior Publisher Correction Smell Mucus [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition Animals Newborn Neurons and Cognition Alimentation et Nutrition physiology Odorants ComputingMethodologies_DOCUMENTANDTEXTPROCESSING [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] lcsh:Q Rabbits business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019) Scientific Reports Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.8111. ⟨10.1038/s41598-019-44135-0⟩ Scientific Reports, 2019, 9 (1), pp.8111. ⟨10.1038/s41598-019-44135-0⟩ Scientific Reports 1 (9), 8111. (2019) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-44135-0 |
| Popis: | In olfaction, to preserve the sensitivity of the response, the bioavailability of odor molecules is under the control of odorant-metabolizing enzymes (OMEs) expressed in the olfactory neuroepithelium. Although this enzymatic regulation has been shown to be involved in olfactory receptor activation and perceptual responses, it remains widely underestimated in vertebrates. In particular, the possible activity of OMEs in the nasal mucus, i.e. the aqueous layer that lined the nasal epithelium and forms the interface for airborne odorants to reach the olfactory sensory neurons, is poorly known. Here, we used the well-described model of the mammary pheromone (MP) and behavioral response in rabbit neonates to challenge the function of nasal mucus metabolism in an unprecedented way. First, we showed, in the olfactory epithelium, a rapid glutathione transferase activity toward the MP by ex vivo real-time mass spectrometry (PTR-MS) which supported an activity in the closest vicinity of both the odorants and olfactory receptors. Indeed and second, both the presence and activity of glutathione transferases were evidenced in the nasal mucus of neonates using proteomic and HPLC analysis respectively. Finally, we strikingly demonstrated that the deregulation of the MP metabolism by in vivo mucus washing modulates the newborn rabbit behavioral responsiveness to the MP. This is a step forward in the demonstration of the critical function of OMEs especially in the mucus, which is at the nasal front line of interaction with odorants and potentially subjected to physiopathological changes. |
| Databáze: | OpenAIRE |
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