Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population

Autor: Sidney Santos, Débora Cristina Ricardo de Oliveira Fernandes, Cleonardo Augusto da Silva, Marianne Rodrigues Fernandes, Maria Clara da Costa Barros, Paulo Pimentel Assumpção, Diana Feio da Veiga Borges Leal, Pablo Pinto, Ney Pereira Carneiro dos Santos, Mayara Natália Santana da Silva, Lucas Favacho Pastana, Juliana Carla Gomes Rodrigues
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Bacterial Diseases
Epidemiology
Population genetics
Geographical locations
0302 clinical medicine
Risk Factors
Medicine and Health Sciences
education.field_of_study
Multidisciplinary
biology
Incidence (epidemiology)
Middle Aged
Actinobacteria
Europe
Infectious Diseases
Medicine
Female
Brazil
Research Article
Tuberculosis
Science
Genetic genealogy
030231 tropical medicine
Population
Black People
Public Policy
Genetic Predisposition
White People
Mycobacterium tuberculosis
03 medical and health sciences
Genetic predisposition
medicine
Genetics
Humans
Risk factor
education
Indigenous Peoples
Evolutionary Biology
Population Biology
Bacteria
Indians
South American
Organisms
Genetic Variation
Biology and Life Sciences
South America
biology.organism_classification
medicine.disease
Tropical Diseases
Genetics
Population
030104 developmental biology
Case-Control Studies
Medical Risk Factors
Genetics of Disease
People and places
Population Genetics
Mycobacterium Tuberculosis
Demography
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0236033 (2020)
ISSN: 1932-6203
Popis: In recent years, the incidence of tuberculosis (TB) has declined worldwide, although this disease still occurs at relatively high rates in Amerindian populations. This suggests that the genetic ancestry of Amerindians may be an important factor in the development of infections, and may account for at least some of the variation in infection rates in the different populations. The present study investigated the potential influence of Amerindian genetic ancestry on susceptibility to tuberculosis in an Amazon population. The study included 280 patients diagnosed with tuberculosis and 138 asymptomatic hospital employees with no history of TB, but who were in contact with bacterially active TB patients. Ancestry analysis was run on a set of 61 Ancestry-Informative Markers to estimate European, African, and Amerindian genetic ancestry using STRUCTURE v2.2. The TB group had significantly higher Amerindian ancestry in comparison with the control group, and significantly lower European ancestry. Amerindian ancestry in the 20-60% range was found to be the principal risk factor for increased susceptibility to TB. The results of the study indicate that Amerindian ancestry is an important risk factor for susceptibility to TB in the admixed population of the Brazilian Amazon region.
Databáze: OpenAIRE
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