Role of a peptidase in phagocyte chemotaxis
| Autor: | Barbara A. Corcoran, Sharon M. Wahl, Elliott Schiffmann, S. Aswanikumar |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Phagocyte
Neutrophils Guinea Pigs Peptide Tosyllysine Chloromethyl Ketone Cleavage (embryo) Structure-Activity Relationship chemistry.chemical_compound medicine Animals Structure–activity relationship Receptor chemistry.chemical_classification N-Formylmethionine Multidisciplinary Chemistry Chemotaxis Macrophages Tosylphenylalanyl Chloromethyl Ketone Complement C5 medicine.anatomical_structure Biochemistry Rabbits Peptides Peptide Hydrolases Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 73:2439-2442 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.73.7.2439 |
| Popis: | The potencies of N-formylmethionyl (fMet) peptides as chemotactic agents for phagocytes are related to the rates at which they are hydrolyzed. Furthermore, chloromethyl ketones inhibit chemotaxis as do the products of hydrolysis of fMet peptides. The directed migration of cells in response to such peptides is probably brought about by the binding of the peptide to a cell receptor with subsequent cleavage by peptidase specific for aromatic residues, a process that allows the chemical gradient to be detected. |
| Databáze: | OpenAIRE |
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