Insulin Resistance and Metabolic Syndrome: Clinical and Laboratory Associations in African Americans Without Diabetes in the Hemochromatosis and Iron Overload Screening Study
| Autor: | Jackson C. Barton, Ronald T. Acton, James C. Barton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Iron Overload Endocrinology Diabetes and Metabolism Body Mass Index Insulin resistance Internal medicine Diabetes mellitus Internal Medicine medicine Humans Hemochromatosis Screening study Aged African american Aged 80 and over Metabolic Syndrome biology business.industry C-reactive protein Age Factors Transferrin nutritional and metabolic diseases Original Articles Middle Aged medicine.disease Black or African American Endocrinology Case-Control Studies Ferritins biology.protein Female Metabolic syndrome Insulin Resistance business Body mass index |
| Popis: | Background: We sought to determine associations with insulin resistance (IR) and metabolic syndrome (MetS) in African Americans. Methods: We studied African American adults without diabetes in a postscreening examination. Participants included Cases: transferrin saturation (TS) >50% and serum ferritin (SF) >300 μg/L (M), and TS >45% and SF >200 μg/L (F), regardless of HFE genotype; and Controls: TS/SF 25th to 75th percentiles and HFE wt/wt (wild type). We excluded participants with fasting 126 mg/dL; hepatitis B or C; cirrhosis; pregnancy; or incomplete datasets. We analyzed age; sex; Case/Control; body mass index (BMI); systolic and diastolic blood pressures; neutrophils; lymphocytes; alanine aminotransferase; aspartate aminotransferase; elevated C-reactive protein (CRP >0.5 mg/L); TS; and SF. We computed homeostasis model assessment of insulin resistance (HOMA-IR) using fasting serum glucose and insulin, and defined IR as HOMA-IR fourth quartile (≥2.42). Results: There were 312 Cases and 86 Controls (56.3% men). Ninety-one percent had HFE wt/wt. None had HFE p.C282Y. A significant increasing trend across HOMA-IR quartiles was observed for BMI only. Multivariable regression on HOMA-IR revealed significant positive associations: age; BMI; lymphocytes; SF; and CRP >0.5 mg/L; and significant negative associations: neutrophils and TS. Logistic regression on IR revealed BMI [odds ratio (OR) 1.3 (95% confidence interval 1.2–1.4)] and CRP >0.5 mg/L [OR 2.7 (1.2–6.3)]. Fourteen participants (3.5%) had MetS. Logistic regression on MetS revealed one association: IR [OR 7.4 (2.1–25.2)]. Conclusions: In African Americans without diabetes, IR was associated with BMI and CRP >0.5 mg/L, after adjustment for other variables. MetS was associated with IR alone. |
| Databáze: | OpenAIRE |
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