Insulin sensitivity in Turner's syndrome: influence of GH treatment
| Autor: | Gianluca Aimaretti, Giorgio Radetti, Elena Gottardi, F. Rigon, Bruno Pasquino, I Boscolo Contadin |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Population Turner Syndrome Endocrinology Internal medicine Diabetes mellitus Glucose Intolerance Turner syndrome Prevalence medicine Humans Child education education.field_of_study Human Growth Hormone business.industry Insulin Quantitative insulin sensitivity check index Type 2 Diabetes Mellitus General Medicine medicine.disease Growth hormone secretion Diabetes Mellitus Type 2 Female Insulin Resistance business Body mass index Follow-Up Studies |
| Zdroj: | European Journal of Endocrinology. :351-354 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1510351 |
| Popis: | OBJECTIVE: Excessive GH secretion may lead to secondary diabetes mellitus, while prolonged GH treatment may accelerate the onset of type 2 diabetes mellitus in predisposed individuals. Turner's syndrome (TS) patients are a population at risk since they have reduced glucose tolerance (GT) spontaneously and because they are usually treated with high doses of GH. DESIGN AND METHODS: The aim of the study was to evaluate insulin sensitivity (IS) and glucose tolerance (GT) in a group of TS patients treated with GH for a period of 6 years. Forty-seven TS girls were included in the study. GH was administered at a mean weekly dosage of 0.35 mg/kg, injected subcutaneously over 6-7 days. GT was assessed according to the criteria of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. IS was evaluated with the quantitative insulin sensitivity check index (QUICK-I). RESULTS: No significant increase of impaired GT was observed in the patients during the follow-up period, while a reduced IS was detected. IS in TS patients was already lower than in prepubertal controls (P |
| Databáze: | OpenAIRE |
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