Investigation of factors relating to neuropsychological change following cardiac surgery
| Autor: | Anton D. Hinton-Bayre, Michael Radel, M. J. Ray, Paul D Raymond, N. A. Marsh |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Neuropsychological Tests 030204 cardiovascular system & hematology law.invention 03 medical and health sciences 0302 clinical medicine Risk Factors law Cardiopulmonary bypass Humans Medicine Radiology Nuclear Medicine and imaging Postoperative Period Coronary Artery Bypass Aged Advanced and Specialized Nursing medicine.diagnostic_test Heparin business.industry Age Factors Neuropsychology General Medicine Neuropsychological test Middle Aged Peptide Fragments Cardiac surgery 030228 respiratory system Elective Surgical Procedures Anesthesia Cohort Female Prothrombin Cognition Disorders Cardiology and Cardiovascular Medicine business Elective Surgical Procedure Safety Research Neurocognitive medicine.drug |
| Zdroj: | Perfusion. 22:27-33 |
| ISSN: | 1477-111X 0267-6591 |
| DOI: | 10.1177/0267659107077952 |
| Popis: | Background. An analysis of neuropsychological impairment following cardiopulmonary bypass was performed in 55 patients undergoing elective coronary artery bypass grafting. Methods. Neurocognitive function was measured preoperatively using the MicroCog: Assessment of Cognitive Functioning computer-based testing tool. Testing was repeated in the postoperative period immediately prior to discharge from hospital. Analysis of significant score decline was performed using the standardised regression-based technique. A patient was classified as overall impaired when ≥20% of test scores were significantly impaired. The proposed marker of neurological damage S-100β was also used. Prothrombin Fragment 1+2 (F1+2) was measured as a marker of thrombin development to test the hypothesis that excessive haemostatic activation may lead to thromboembolic damage to the brain. Results and Conclusions. 32.7% of patients were classified as significantly impaired. No relationship was detected between F1+2 and any neuropsychological test score; however, the study was limited due to small sample size. F1+2 levels were higher in patients undergoing prolonged bypass times. Neuropsychological decline was significantly correlated with patient age, suggesting a degree of caution is warranted when operating on an elderly cohort. An unexpected relationship was detected between higher heparin concentrations and increased risk of neuropsychological impairment; however, this requires re-evaluation. Perfusion (2007) 22, 27—33. |
| Databáze: | OpenAIRE |
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