Assessing the value of matrix metalloproteinase 9 (MMP9) in improving the appropriateness of referrals for colorectal cancer
| Autor: | Scott Wilson, Stephen T. Ward, Jonathan James, Linda Nichols, Sarah Damery, Michael J.O. Wakelam, Sally Warmington, Tariq Ismail, Roger Holder |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty matrix metalloproteinase Referral Colorectal cancer diagnosis Population colorectal cancer Logistic regression 03 medical and health sciences Young Adult 0302 clinical medicine Diabetes mellitus Internal medicine medicine Biomarkers Tumor Blood test Humans Young adult education Molecular Diagnostics Referral and Consultation 030304 developmental biology risk Aged Aged 80 and over 0303 health sciences Univariate analysis education.field_of_study medicine.diagnostic_test business.industry Middle Aged medicine.disease 3. Good health Surgery Oncology Matrix Metalloproteinase 9 030220 oncology & carcinogenesis referral Female business Colorectal Neoplasms serum |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background: A blood test may be an effective means of improving the appropriateness of referrals for symptomatic patients referred to specialist colorectal clinics. We evaluated the accuracy of a serum matrix metalloproteinase (MMP9) test in indicating colorectal cancer or its precursor conditions in a symptomatic population. Methods: Patients aged over 18, referred urgently or routinely to secondary care following primary care presentation with colorectal symptoms completed a questionnaire and provided a blood sample for serum MMP9 estimation. Univariate analysis and logistic regression modelling investigated the association between presenting symptoms, MMP9 measurements and the diagnostic outcome of patient investigations, in order to derive the combination of factors which best predicted a high risk of malignancy. Results: Data were analysed for 1002 patients. Forty-seven cases of neoplasia were identified. Age, male gender, absence of anal pain, diabetes, blood in stools, urgent referral, previous bowel polyps and previous bowel cancer were significantly associated with neoplasia. Matrix metalloproteinase 9 measurements were not found to be associated with significant colorectal pathology. Conclusion: This study, despite robust sampling protocols, showed no clear association between MMP9 and colorectal neoplasia. Matrix metalloproteinase 9 therefore appears to have little value as a tool to aid referral decisions in the symptomatic population. |
| Databáze: | OpenAIRE |
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