Contraction behaviour reduces embryo competence in high-quality euploid blastocysts
| Autor: | S Seshadri, Matthew Gaunt, Paul Serhal, Rabi Odia, Wael Saab, Xavier Viñals Gonzalez, Suzanne Cawood |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Monosomy Contraction (grammar) Fertilization in Vitro Biology Andrology 03 medical and health sciences 0302 clinical medicine Pregnancy Genetics medicine Humans Blastocyst Embryo Implantation Genetic Testing Genetics (clinical) Preimplantation Diagnosis 030219 obstetrics & reproductive medicine Mosaicism Obstetrics and Gynecology Correction Embryo General Medicine Blastula medicine.disease Aneuploidy Embryo Biology 030104 developmental biology medicine.anatomical_structure Reproductive Medicine embryonic structures Female Ploidy Trisomy Chromosome 21 Developmental Biology |
| Popis: | PURPOSE: The aim of the study is to investigate how blastocyst contraction behaviour affects the reproductive competence in high-quality euploid embryos. METHODS: Eight hundred ninety-six high-quality blastocysts derived from 190 patients (mean age 38.05 (SD = 2.9) years) who underwent preimplantation genetic testing for aneuploidies (PGT-A) from January 2016 to October 2017 were included in this study. PGT-A results were reported as euploid or aneuploid. Aneuploid embryos were sub-classified into three categories: monosomy, trisomy and complex aneuploid. Retrospective studies of time-lapse monitoring (TLM) of those embryos were analysed and reproductive outcome of transferred embryos was collected. RESULTS: A total of 234/896 were euploid (26.1%) whilst 662/896 (73.9%) blastocysts were proven to be aneuploid from which 116 (17.6%) presented monosomies, 136 (20.5%) trisomies and 410 (61.9%) were complex aneuploid. The most frequent chromosomal complements were trisomies affecting chromosome 21 and monosomies involving chromosomes 16 and 22. Data analysis showed a statistical difference in the number of contractions being reported greater in aneuploid when compared to euploid embryos (0.6 vs 1.57; p |
| Databáze: | OpenAIRE |
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