Labdane-Type Diterpenoids from the Fruits of Vitex trifolia
| Autor: | Cheng-Jian Zheng, Khalid Rahman, Wu Yu, Lu-Ping Qin, Jian-Yong Zhu, Xue-Qin Ma |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Stereochemistry
Pharmaceutical Science HL-60 Cells Analytical Chemistry Vitex Labdane Inhibitory Concentration 50 chemistry.chemical_compound Vitex trifolia Drug Discovery Humans Inhibitory concentration 50 Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure biology Chemistry Organic Chemistry Data interpretation HCT116 Cells biology.organism_classification Complementary and alternative medicine Fruit Molecular Medicine Diterpenes Drug Screening Assays Antitumor Algorithms Human cancer |
| Zdroj: | Journal of Natural Products. 76:287-291 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Seven new labdane-type diterpenoids, vitextrifolins A–G (1–7), along with eight previously reported analogues, were isolated from the fruits of Vitex trifolia. The structures of 1–7 were elucidated by spectroscopic data interpretation. The isolates were evaluated for their cytotoxicity against four human cancer cell lines (A549, HCT116, HL-60, and ZR-75-30), but all were inactive (IC50 < 5 μg/mL). |
| Databáze: | OpenAIRE |
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