Environmental influences that affect attention deficit/hyperactivity disorder: study of a genetic isolate
| Autor: | Clara P. Arango, Daniel Camilo Aguirre, Francisco Lopera, Mónica Uribe Gómez, David Pineda, Puerta Ic, Luis G Palacio, Mauricio Arcos-Burgos, Vilma Merchán, Astrid Yuleth Galvis |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Health Status Colombia Miscarriage Pregnancy Risk Factors Developmental and Educational Psychology Child and adolescent psychiatry medicine Prevalence Attention deficit hyperactivity disorder Humans Risk factor Psychiatry Child Hypoxia Asphyxia Asphyxia Neonatorum Infant Newborn General Medicine Odds ratio Environmental Exposure medicine.disease Diagnostic and Statistical Manual of Mental Disorders Pregnancy Complications Psychiatry and Mental health El Niño Attention Deficit Disorder with Hyperactivity Pediatrics Perinatology and Child Health Female medicine.symptom Psychology Cognition Disorders |
| Zdroj: | European childadolescent psychiatry. 16(5) |
| ISSN: | 1018-8827 |
| Popis: | Three independent complex segregation analyses found that the cause of Attention Deficit/Hyperactivity Disorder (ADHD) was the presence of major genes interacting with environmental influences. In order to identify potential environmental risk factors for ADHD in the Paisa community--a very well described, genetically isolated group--we randomly selected a sample of 486 children between 6 and 11 years of age. This group included 200 children with ADHD (149 males and 51 females) and 286 healthy controls (135 males and 151 females). The ADHD DSM-IV diagnosis was obtained using the DICA and BASC evaluation instruments, and the children's mothers or grandmothers filled out a questionnaire on each child's exposure to prenatal, neonatal, and early childhood risk factors. The data were analyzed using cross tabulation and stepwise logistic multiple-regression analyses. Cross tabulation associated ADHD with a variety of factors, including miscarriage symptoms, premature delivery symptoms, maternal respiratory viral infection, moderate to severe physical illness in the mother during gestation, prenatal cigarette and alcohol exposure, neonatal seizures, asphyxia or anoxia, severe neonatal illness, mild speech retardation, moderate brain injury, and febrile seizures (odds ratioor= 2, P0.05). Stepwise logistic multiple-regression analysis also uncovered a block of variables, including male gender, maternal illnesses, prenatal alcohol exposure, mild speech retardation, febrile seizures, and moderate brain injury (odds ratioor= 2.0, P0.05). Future studies on the risk of developing ADHD must include these environmental factors as covariates. |
| Databáze: | OpenAIRE |
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