Kwun J, Burghuber C, Manook M, et al. Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates. Blood Adv. 2017;1(24):2115-2119

Autor:	Jean Kwun, Allan Kirk
Rok vydání:	2018
Předmět:	Hematology Erratum
Zdroj:	Blood Advances. 2:89-89
ISSN:	2473-9537 2473-9529
DOI:	10.1182/bloodadvances.2017015446
Popis:	The detrimental effects of donor-directed antibodies in sensitized transplant patients remain a difficult immunologic barrier to successful organ transplantation. Antibody removal is often followed by rebound. Proteasome inhibitors (PIs) deplete antibody-producing plasma cells (PCs) but have shown marginal benefit for desensitization. In an allosensitized nonhuman primate (NHP) model, we observed increased germinal center (GC) formation after PI monotherapy, suggesting a compensatory PC repopulation mediated via GC activation. Here we show that costimulation blockade (CoB) targets GC follicular helper T (Tfh) cells in allosensitized NHPs. Combined PI and CoB significantly reduces bone marrow PCs (CD19
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69097e84e732f1ee440d0d6fa8e0400d https://doi.org/10.1182/bloodadvances.2017015446 Zobrazit plný text záznamu