Oxidative metabolism of the brain in the experimental cerebral edema
| Autor: | A. Dincă, R. Chirvasie, B. Schwartz, E. Păuşescu |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
medicine.medical_specialty
Acid Phosphatase Brain Edema Dehydrogenase Oxidative phosphorylation Oxidative Phosphorylation Cerebral edema Dogs Developmental Neuroscience Internal medicine Edema medicine Animals Transferase Transaminases chemistry.chemical_classification biology Acid phosphatase Brain Water Alkaline Phosphatase medicine.disease Isocitrate Dehydrogenase Succinate Dehydrogenase Enzyme Endocrinology Neurology chemistry biology.protein Alkaline phosphatase medicine.symptom Oxidoreductases Dinitrophenols |
| Zdroj: | Experimental Neurology. 19:455-462 |
| ISSN: | 0014-4886 |
| DOI: | 10.1016/0014-4886(67)90165-3 |
| Popis: | The interrelation of the cerebral water content on the activity of some cerebral enzymes was studied in dogs with experimental edema of the brain. NAD-specific isocitric dehydrogenase, glutamyl transferase and acid phosphatase activity were found to be increased in the edematous cerebral tissue, while succinic dehydrogenase, α-ketoglutaric dehydrogenase and alkaline phosphatase activity were unmodified; 2,4-dinitrophenol did not induce depression of the ability of edematous cerebral tissue to oxidize isocitrate, α-ketoglutarate and succinate. These observations suggest that the effect of cerebral edema may be related to decreased high-energy phosphate metabolism with subsequent alteration of oxidative phosphorilation of some substrates. |
| Databáze: | OpenAIRE |
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