Embolization biomaterial reinforced with nanotechnology for an in-situ release of anti-angiogenic agent in the treatment of hyper-vascularized tumors and arteriovenous malformations

Autor: Laurence Moine, Laurent Bédouet, Florentina Pascale, J.P. Saint-Maurice, Alexandre Laurent, Denis Labarre, Najet Yagoubi, K. Slimani, Emile Jubeli
Přispěvatelé: Université Paris-Sud - Paris 11 (UP11), Institut National de la Recherche Agronomique (INRA), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance Publique - Hopitaux de Paris: 'fonds d'amorcage biotherapie AP-HP', BOOSTER innovation
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Indoles
Angiogenesis
Drug Compounding
medicine.medical_treatment
Anti-angiogenic
[SDV]Life Sciences [q-bio]
Pharmaceutical Science
Angiogenesis Inhibitors
Biocompatible Materials
Intercostal Muscles
Nanotechnology
Arteriovenous Malformations
Cornea
Embolic Agent
Arteriovenous malformation
Random Allocation
chemistry.chemical_compound
Embolization
Drug Delivery Systems
In vivo
Human Umbilical Vein Endothelial Cells
medicine
Sunitinib
Animals
Pyrroles
Cells
Cultured
Sheep
Domestic
Cell Proliferation
Acrylate
Gelling solution
Neovascularization
Pathologic
business.industry
Arterial Embolization
Biomaterial
General Medicine
medicine.disease
Embolization
Therapeutic
3. Good health
Acrylates
chemistry
Delayed-Action Preparations
Corneal neovascularization
Endothelium
Vascular
Rabbits
business
Gels
Nanospheres
Biotechnology
Zdroj: European Journal of Pharmaceutics and Biopharmaceutics
European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2015, 96, pp.396-408. ⟨10.1016/j.ejpb.2015.09.006⟩
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2015.09.006⟩
Popis: International audience; A polymer based material was developed to act as an embolic agent and drug reservoir for the treatment of arteriovenous malformations (AVM) and hyper vascularized solid tumors. The aim was to combine the blocking of blood supply to the target region and the inhibition of the embolization-stimulated angiogenesis. The material is composed of an ethanolic solution of a linear acrylate based copolymer and acrylate calibrated microparticles containing nanospheres loaded with sunitinib, an anti-angiogenic agent. The precipitation of the linear copolymer in aqueous environment after injection through microcatheter results in the formation of an in-situ embolization gel whereas the microparticles serve to increase the cohesive properties of the embolization agent and to form a reservoir from which the sunitinib-loaded nanospheres are released post-embolization. The swollen state or the microparticles in contact with aqueous medium results in the release of the nanospheres out of microparticles macromolecular structure. After the synthesis, the formulation and the characterization of the different components of the material, anti-angiogenic activity was evaluated in vitro using endothelial cells and in vivo using corneal neovascularization model in rabbit. The efficiency of the arterial embolization was tested in vivo in a sheep model. Results proved the feasibility of this new system for vascular embolization in association with an in situ delivery of anti-angiogenic drug. This combination is a promising strategy for the management of arteriovenous malformations and solid tumors.
Databáze: OpenAIRE
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