Young, active and well-connected: adult-born neurons in the zebra finch are activated during singing
| Autor: | Kirill Tokarev, Gala A. E. Claßen, Constance Scharff, Arjen J. Boender |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
Male animal structures Histology High Vocal Center Neurogenesis Biology Motor behaviour Synapse Avian Proteins 03 medical and health sciences 0302 clinical medicine Homeostatic plasticity Neural Pathways medicine Animals Zebra finch Early Growth Response Protein 1 Neurons Neuronal Plasticity General Neuroscience 030104 developmental biology medicine.anatomical_structure nervous system Acoustic Stimulation behavior and behavior mechanisms Auditory stimuli Auditory Perception Finches Anatomy Singing Vocalization Animal Neuroscience Nucleus Proto-Oncogene Proteins c-fos psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Brain structurefunction. 221(4) |
| ISSN: | 1863-2661 |
| Popis: | Neuronal replacement in the pallial song control nucleus HVC of adult zebra finches constitutes an interesting case of homeostatic plasticity; in spite of continuous addition and attrition of neurons in ensembles that code song elements, adult song remains remarkably invariant. New neurons migrate into HVC and later synapse with their target, arcopallial song nucleus RA (HVCRA). New HVCRA neurons respond to auditory stimuli (in anaesthetised animals), but whether and when they become functionally active during singing is unknown. We studied this, using 5-bromo-2′-deoxyuridine to birth-date neurons, combined with immunohistochemical detection of immediate-early gene (IEG) expression and retrograde tracer injections into RA to track connectivity. Interestingly, singing was followed by IEG expression in a substantial fraction of new neurons that were not retrogradely labelled from RA, suggesting a possible role in HVC-intrinsic network function. As new HVC neurons matured, the proportion of HVCRA neurons that expressed IEGs after singing increased significantly. Since it was previously shown that singing induces IEG expression in HVC also in deaf birds and that hearing song does not induce IEG expression in HVC, our data provide the first direct evidence that new HVC neurons are engaged in song motor behaviour. |
| Databáze: | OpenAIRE |
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