Bio-mineralization of virus-like particles by metal–organic framework nanoparticles enhances the thermostability and immune responses of the vaccines
| Autor: | Zhidong Teng, Fengping Hou, Manyuan Bai, Jiajun Li, Jun Wang, Jinen Wu, Jiaxi Ru, Mei Ren, Shiqi Sun, Huichen Guo |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
health care facilities
manpower and services viruses Immunity Biomedical Engineering virus diseases General Chemistry General Medicine biochemical phenomena metabolism and nutrition complex mixtures Foot-and-Mouth Disease Virus Animals Nanoparticles General Materials Science Vaccines Virus-Like Particle Metal-Organic Frameworks |
| Zdroj: | Journal of Materials Chemistry B. 10:2853-2864 |
| ISSN: | 2050-7518 2050-750X |
| Popis: | Virus-like particle (VLPs) vaccines have been extensively studied due to their good immunogenicity and safety; however, they highly rely on cold-chain storage and transportation. Nanotechnology of bio-mineralization as a useful strategy has been employed to improve the thermal stability and immunogenicity of VLPs. A zeolitic imidazole framework (ZIF-8), a core-shell structured nanocomposite, was applied to encapsulate foot-and-mouth disease virus (FMDV) VLPs. It was found that the ZIF-8 shell enhanced the heat resistance of VLPs and promoted their ability to be taken up by cells and escape from lysosomes. The VLPs-ZIF-8 easily activated antigen-presenting cells (APCs), triggered higher secretion levels of cytokines, and elicited stronger immune responses than VLPs alone even after being treated at 37 °C for 7 days. This platform has good potential in the development of VLP-based vaccine products without transportation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|