The feasibility of measuring frailty to predict disability and mortality in older medical intensive care unit survivors
| Autor: | Hannah Wunsch, Mathew S. Maurer, Nathan E. Goldstein, Amanda A. Westlake, David J. Lederer, Thuy-Tien L. Dam, John W. Rowe, Daniel Rabinowitz, M. Cary Reid, Evelyn C. Granieri, Matthew R. Baldwin |
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| Rok vydání: | 2013 |
| Předmět: |
Gerontology
Male medicine.medical_specialty Activities of daily living Critical Care medicine.medical_treatment Frail Elderly Critical Care and Intensive Care Medicine Rate ratio Article law.invention Disability Evaluation law Intensive care Activities of Daily Living medicine Humans Disabled Persons Prospective Studies Survivors Mortality Prospective cohort study APACHE Aged Proportional Hazards Models Mechanical ventilation Aged 80 and over business.industry Proportional hazards model Middle Aged Intensive care unit Respiration Artificial Patient Discharge Intensive Care Units Respiratory failure Emergency medicine Feasibility Studies Female business Respiratory Insufficiency |
| Zdroj: | Journal of critical care. 29(3) |
| ISSN: | 1557-8615 |
| Popis: | Purpose To determine whether frailty can be measured within 4 days prior to hospital discharge in older intensive care unit (ICU) survivors of respiratory failure and whether it is associated with post-discharge disability and mortality. Materials and Methods We performed a single-center prospective cohort study of 22 medical ICU survivors age 65 years or older who had received noninvasive or invasive mechanical ventilation for at least 24 hours. Frailty was defined as a score of ≥3 using Fried's 5-point scale. We measured disability with the Katz Activities of Daily Living. We estimated unadjusted associations between Fried's frailty score and incident disability at 1-month and 6-month mortality using Cox proportional hazard models. Results The mean (SD) age was 77 (9) years, mean Acute Physiology and Chronic Health Evaluation II score was 27 (9.7), mean frailty score was 3.4 (1.3), and 18 (82%) were frail. Nine subjects (41%) died within 6 months, and all were frail. Each 1-point increase in frailty score was associated with a 90% increased rate of incident disability at 1-month (rate ratio: 1.9, 95% CI 0.7-4.9) and a threefold increase in 6-month mortality (rate ratio: 3.0, 95% CI 1.4-6.3). Conclusions Frailty can be measured in older ICU survivors near hospital discharge and is associated with 6-month mortality in unadjusted analysis. Larger studies to determine if frailty independently predicts outcomes are warranted. |
| Databáze: | OpenAIRE |
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