Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer’s Disease
| Autor: | Corey Giles, Ashley I. Bush, David Ames, Ian Martins, Victor L. Villemagne, Kevin Huynh, Kaushala S. Jayawardana, Christopher C. Rowe, Colin L. Masters, Brian G. Drew, Wei Ling Florence Lim, Simon M. Laws, Natalie A. Mellett, Peter J. Meikle, Ralph N. Martins, Pratishtha Chatterjee |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Apolipoprotein E Aging Apolipoprotein E4 Physiology APOEɛ4 Disease 03 medical and health sciences chemistry.chemical_compound Sex Factors 0302 clinical medicine Alzheimer Disease Risk Factors Lipidomics gender medicine Humans lipid species Longitudinal Studies Aged Aged 80 and over business.industry alpha-Linolenic acid General Neuroscience Australia Lipid metabolism General Medicine Lipidome Lipid Metabolism medicine.disease Lipids Sphingolipid Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies 030104 developmental biology chemistry Female lipids (amino acids peptides and proteins) Geriatrics and Gerontology Alzheimer's disease business Alzheimer’s disease Biomarkers 030217 neurology & neurosurgery Follow-Up Studies Research Article |
| Zdroj: | Journal of Alzheimer's Disease |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-191304 |
| Popis: | Background Lipid metabolism is altered in Alzheimer's disease (AD); however, the relationship between AD risk factors (age, APOEɛ4, and gender) and lipid metabolism is not well defined. Objective We investigated whether altered lipid metabolism associated with increased age, gender, and APOE status may contribute to the development of AD by examining these risk factors in healthy controls and also clinically diagnosed AD individuals. Methods We performed plasma lipidomic profiling (582 lipid species) of the Australian Imaging, Biomarkers and Lifestyle flagship study of aging cohort (AIBL) using liquid chromatography-mass spectrometry. Linear regression and interaction analysis were used to explore the relationship between risk factors and plasma lipid species. Results We observed strong associations between plasma lipid species with gender and increasing age in cognitively normal individuals. However, APOEɛ4 was relatively weakly associated with plasma lipid species. Interaction analysis identified differential associations of sphingolipids and polyunsaturated fatty acid esterified lipid species with AD based on age and gender, respectively. These data indicate that the risk associated with age, gender, and APOEɛ4 may, in part, be mediated by changes in lipid metabolism. Conclusion This study extends our existing knowledge of the relationship between the lipidome and AD and highlights the complexity of the relationships between lipid metabolism and AD at different ages and between men and women. This has important implications for how we assess AD risk and also for potential therapeutic strategies involving modulation of lipid metabolic pathways. |
| Databáze: | OpenAIRE |
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