Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa
| Autor: | J Kremen, Tereza Kumstyrová, K Anderlová, Denisa Haluzikova, Martin Haluzik, Jitka Housova, Jarmila Krizova, Hana Papezova |
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| Rok vydání: | 2004 |
| Předmět: |
Blood Glucose
Leptin medicine.medical_specialty Anorexia Nervosa Endocrinology Diabetes and Metabolism Clinical Biochemistry Adipose tissue Receptors Cell Surface Biochemistry Body Mass Index Endocrinology Internal medicine Medicine Homeostasis Humans Insulin Resistin Bulimia Adiponectin business.industry Bulimia nervosa Biochemistry (medical) nutritional and metabolic diseases medicine.disease Eating disorders Adipose Tissue Anorexia nervosa (differential diagnoses) Hormones Ectopic Intercellular Signaling Peptides and Proteins Receptors Leptin Female business Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 90(3) |
| ISSN: | 0021-972X |
| Popis: | To study the role of adipose tissue-derived hormones in the pathophysiology of eating disorders, circulating levels of adiponectin, resistin, and other hormonal and metabolic parameters were measured in 16 females with the restrictive subtype of anorexia nervosa (R-AN), 10 females with the binge/purge subtype of anorexia nervosa (P-AN), 15 females with bulimia nervosa (BN), and 12 age-matched healthy females (C). Body mass index (BMI), body fat content, and serum leptin levels were severely decreased in R-AN and moderately decreased in P-AN patients, whereas the BN group did not differ from C in these parameters. Serum soluble leptin receptor levels were increased in R-AN and P-AN and unchanged in BN patients. Circulating adiponectin levels were inversely related to BMI and were unchanged in BN patients and increased by 53% in P-AN and by 96% in R-AN relative to C group, respectively. In contrast, resistin levels in malnourished R-AN and P-AN were not different from either C or BN groups and showed no significant relationship to BMI or body fat content. We suggest that increased adiponectin levels reflect decreased body fat content in AN patients. In contrast, circulating resistin levels do not appear to be closely related to the nutritional status. |
| Databáze: | OpenAIRE |
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