Impaired anorectic effect of leptin in neurotensin receptor 1-deficient mice
| Autor: | Arnold Leckstrom, Tooru M. Mizuno, Eun Ran Kim |
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| Rok vydání: | 2008 |
| Předmět: |
Blood Glucose
Leptin medicine.medical_specialty Neurotensin receptor 1 media_common.quotation_subject Hypothalamus Adipokine Biology Calorimetry Hyperphagia Motor Activity Body Temperature Behavioral Neuroscience chemistry.chemical_compound Eating Mice Internal medicine Appetite Depressants medicine Animals Receptors Neurotensin Neurotensin receptor Neurotensin media_common Mice Knockout Analysis of Variance Leptin receptor Behavior Animal digestive oral and skin physiology Body Weight Appetite Mice Inbred C57BL Endocrinology chemistry Gene Expression Regulation Anorectic hormones hormone substitutes and hormone antagonists |
| Zdroj: | Behavioural brain research. 194(1) |
| ISSN: | 0166-4328 |
| Popis: | Neurotensin plays a role in regulating feeding behavior. Central injection of neurotensin reduces food intake and the anorectic effect of neurotensin is mediated through neurotensin receptor 1 (Ntsr1). Ntsr1-deficient mice are characterized by mild hyperphagia and overweight without hyperleptinemia. The mechanism by which Ntsr1-deficient mice develop these metabolic abnormalities is not well understood. Leptin, secreted by adipocytes, regulates food intake by acting on hypothalamic neurons including neurotensin-producing neurons. Since the anorectic effect of leptin is blocked by neurotensin receptor antagonist, we hypothesized that the anorectic effect of leptin is mediated through Ntsr1 in the central nervous system and that decreased sensitivity to the anorectic effect of leptin contributes to metabolic perturbations in Ntsr1-deficient mice. To address this hypothesis, we examined the effect of intracerebroventricular (i.c.v.) administration of leptin on food intake in Ntsr1-deficient mice. A single i.c.v. injection of leptin caused robust reductions in food intake in wild-type mice. These effects were markedly attenuated in Ntsr1-deficient mice. These data are consistent with our hypothesis that the anorectic effect of leptin is at least partly mediated through central Ntsr1 and that the leptin-Ntsr1 signaling pathway is involved in the regulation of food intake. Our data also suggest that the lack of Ntsr1 reduces sensitivity to the anorectic action of leptin, causing hyperphagia and abnormal weight gain. |
| Databáze: | OpenAIRE |
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