Synergistic inhibition of replication of human immunodeficiency virus type 1, including that of a zidovudine-resistant isolate, by zidovudine and 2',3'-dideoxycytidine in vitro
| Autor: | Debra P. Merrill, M. S. Hirsch, Ting-Chao Chou, Victoria A. Johnson, Joseph J. Eron |
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| Rok vydání: | 1992 |
| Předmět: |
viruses
Biology Virus Replication Virus Zalcitabine Zidovudine immune system diseases 2'3' dideoxycytidine medicine Humans heterocyclic compounds Pharmacology (medical) Cytotoxicity Pharmacology virus diseases Drug Synergism biochemical phenomena metabolism and nutrition Drug interaction Virology In vitro Drug Combinations Infectious Diseases Viral replication HIV-1 Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 36:1559-1562 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | The combination of zidovudine (AZT) and 2',3'-dideoxycytidine synergistically inhibits human immunodeficiency virus type 1 (HIV-1) replication in vitro with AZT-sensitive and AZT-resistant clinical isolates and HIV-1IIIB. Synergy was determined by the median-effect principle and isobologram techniques. Cytotoxicity of the agents was not observed. Clinical trials are ongoing to define the combination's role in HIV-1 therapy. |
| Databáze: | OpenAIRE |
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