Syngeneic renal transplantation increases the number of renal dendritic cells in the rat
| Autor: | D. Rohan Jeyarajah, Jeffrey G Penfield, Christopher Y. Lu, Mariusz A. Kielar, Aamer Ar'Rajab, Ingemar Dawidson |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.drug_class Immunology Cell Count Major histocompatibility complex Monoclonal antibody Cell Movement medicine Animals Immunology and Allergy Cytotoxic T cell Kidney transplantation Transplantation Kidney biology Follicular dendritic cells business.industry Histocompatibility Antigens Class II Dendritic Cells medicine.disease Kidney Transplantation Rats Transplant rejection surgical procedures operative medicine.anatomical_structure Rats Inbred Lew biology.protein business |
| Zdroj: | Transplant Immunology. 7:197-200 |
| ISSN: | 0966-3274 |
| DOI: | 10.1016/s0966-3274(99)80002-1 |
| Popis: | Dendritic cells participate in the regulation of CD4 and CD8 T cells during transplant rejection. Understanding what causes increased numbers of dendritic cells to appear in the renal transplant is therefore important. We performed syngeneic renal transplants between rats. We used the monoclonal antibody OX62 to detect dendritic cells, and OX6 to detect major histocompatability complex (MHC) Class II in the renal transplant. One week after transplant, dendritic cells appeared. This indicates that the injury of transplantation itself is sufficient to increase the number of dendritic cells in the kidney in a model where there is no alloreactivity. |
| Databáze: | OpenAIRE |
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