Disruption of structural brain networks in Primary Open Angle Glaucoma
| Autor: | F. Di Giuliano, Luca Passamonti, Roberto Floris, Eliseo Picchi, Carlo Nucci, Nicola Toschi, F. Di Cio, Silvia Minosse, M. Guerrisi, Alessio Martucci, Simona Lanzafame, Francesco Garaci, Raffaele Mancino |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Open angle glaucoma
genetic structures Central nervous system Glaucoma Disease Brain mapping Probabilistic tractography 03 medical and health sciences 0302 clinical medicine Settore MED/30 medicine Disconnection syndrome Humans Gray Matter Brain Mapping business.industry Brain Settore MED/37 medicine.disease eye diseases medicine.anatomical_structure Diffusion Magnetic Resonance Imaging 030221 ophthalmology & optometry sense organs business Neuroscience 030217 neurology & neurosurgery Glaucoma Open-Angle Diffusion MRI |
| Zdroj: | 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), pp. 1705–1708, Montreal (Canada), 20-24 July 2020 info:cnr-pdr/source/autori:Di Cio F.; Garaci F.; Minosse S.; Passamonti L.; Martucci A.; Lanzafame S.; Di Giuliano F.; Picchi E.; Mancino R.; Guerrisi M.; Nucci C.; Floris R.; Toschi N./congresso_nome:42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)/congresso_luogo:Montreal (Canada)/congresso_data:20-24 July 2020/anno:2020/pagina_da:1705/pagina_a:1708/intervallo_pagine:1705–1708 EMBC |
| ISSN: | 2694-0604 |
| Popis: | Primary open angle glaucoma (POAG) is one of the most common causes of permanent blindness in the world. Recent studies have originated the hypothesis that POAG could be considered as a central nervous system pathology which results in secondary visual involvement. The aim of this study is to assess possible structural whole brain connectivity alterations in POAG by combining multi-shell diffusion weighted imaging, multi-shell multi-tissue probabilistic tractography, graph theoretical measures and a newly designed disruption index, which evaluates the global reorganization of brain networks in group-wise comparisons. We found global differences in structural connectivity between Glaucoma patients and controls, as well as in local graph theoretical measures. These changes extended well beyond the primary visual pathway. Furthermore, group-wise and subject-wise disruption indices were found to be statistically different between glaucoma patients and controls, with a positive slope. Overall, our results support the hypothesis of a whole-brain structural reorganization in glaucoma which is specific to structural connectivity, possibly placing this disease within the recently defined groups of brain disconnection syndrome. |
| Databáze: | OpenAIRE |
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