Interaction between graviception and carotid baroreflex function in humans during parabolic flight-induced microgravity
| Autor: | Peter B. Raven, Shigehiko Ogoh, Pierre Denise, Michaël Marais, Romain Lericollais, Hervé Normand |
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| Přispěvatelé: | Toyo University, Cognition, Mobilités, Temporalité (COMETE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology [SDV]Life Sciences [q-bio] Parabolic flight 030204 cardiovascular system & hematology Baroreflex Young Adult 03 medical and health sciences 0302 clinical medicine Heart Rate Physiology (medical) Internal medicine [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Humans Medicine Arterial Pressure ComputingMilieux_MISCELLANEOUS Vestibular system Blood Volume Weightlessness business.industry Arterial baroreflex Carotid Arteries Carotid Sinus Blood pressure cardiovascular system Cardiology Female sense organs business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology 030217 neurology & neurosurgery |
| Zdroj: | Journal of Applied Physiology Journal of Applied Physiology, American Physiological Society, 2018, 125 (2), pp.634-641. ⟨10.1152/japplphysiol.00198.2018⟩ |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00198.2018 |
| Popis: | The aim of the present study was to assess carotid baroreflex (CBR) function during acute changes in otolithic activity in humans. To address this question, we designed a set of experiments to identify the modulatory effects of microgravity on CBR function at a tilt angle of −2°, which was identified to minimize changes in central blood volume during parabolic flight. During parabolic flight at 0 and 1 g, CBR function curves were modeled from the heart rate (HR) and mean arterial pressure (MAP) responses to rapid pulse trains of neck pressure and neck suction ranging from +40 to −80 Torr; CBR control of HR (carotid-HR) and MAP (carotid-MAP) function curves, respectively. The maximal gain of both carotid-HR and carotid-MAP baroreflex function curves were augmented during microgravity compared with 1 g (carotid-HR, −0.53 to −0.80 beats·min−1·mmHg−1, P < 0.05; carotid-MAP, −0.24 to −0.30 mmHg/mmHg, P < 0.05). These findings suggest that parabolic flight-induced acute change of otolithic activity may modify CBR function and identifies that the vestibular system contributes to blood pressure regulation under fluctuations in gravitational forces. NEW & NOTEWORTHY The effect of acute changes in vestibular activity on arterial baroreflex function remains unclear. In the present study, we assessed carotid baroreflex function without changes in central blood volume during parabolic flight, which causes acute changes in otolithic activity. The sensitivity of both carotid heart rate and carotid mean arterial pressure baroreflex function was augmented in microgravity compared with 1 g, suggesting that the vestibular system contributes to blood pressure regulation in humans on Earth. |
| Databáze: | OpenAIRE |
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