The prognostic value of nitrotyrosine levels in coronary heart disease: long-term evaluation in the Acute Coronary Syndrome Registry Strategy (ERICO study)
| Autor: | Alessandra V. L. Quidim, Alessandra C. Goulart, Paola Caroline Lacerda Leocádio, Paulo A. Lotufo, Penélope Lacrísio dos Reis Menta, Isabela M. Benseñor, Tatiana Cristina Bruno, Itamar S. Santos, Jacqueline I. Alvarez-Leite |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
030213 general clinical medicine medicine.medical_specialty Acute coronary syndrome Time Factors Clinical Biochemistry Coronary Disease Kaplan-Meier Estimate 030204 cardiovascular system & hematology Angina 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Humans Medicine Prospective Studies Myocardial infarction Acute Coronary Syndrome Prospective cohort study Aged business.industry Unstable angina Proportional hazards model Mortality rate General Medicine Middle Aged Prognosis medicine.disease MORTALIDADE Confidence interval Survival Rate Cardiology Tyrosine Female business Biomarkers |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0009-9120 |
| Popis: | Introduction We aimed to analyze the association of nitrotyrosine (N-TYR) levels and long-term survival in an ongoing coronary heart disease (CHD) prospective cohort, the Acute Coronary Syndrome Registry Strategy (ERICO study). Methods N-TYR levels collected during acute and subacute phase from onset of acute coronary syndrome (ACS) symptoms (myocardial infarction and unstable angina) were evaluated in 342 patients. We calculated case-fatality rates (180-days, 1 year, 2 years and 4 years) and survival analyses up to 4 years using Kaplan-Meier curves and Cox regression with respective cumulative hazard ratios (95% confidence interval; 95%CI), according to N-TYR tertiles up to 4 years of follow-up. Models are presented as crude, age and sex-adjusted and further adjusted for lipids and other confounders. Results Overall, median level of N-TYR was 208.33 nmol/l (range: 3.09 to 1500 nmol/l), regardless ACS subtype. During follow-up of 4 years, we observed 44 (12.9%) deaths. Overall survival rate was 298 (87.1%) (Survival days: 1353, 95%CI: 1320–1387 days). N-TYR levels did not associate with mortality / survival rates up to 4 years. Conclusions No relationship was found between N-TYR levels and mortality rates after ACS during 4-year follow-up in the ERICO study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect