Mutagenic and cytostatic activities of the Xylopia laevigata essential oil in human lymphocytes
| Autor: | Emmanoel V. Costa, Giovana N. M. Esquissato, Tais Susane Pereira, Paulo Cesar de Lima Nogueira, Marialba Avezum Alves de Castro-Prado |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Mitotic index
Proliferation index Traditional medicine biology 010405 organic chemistry Chemistry Organic Chemistry Plant Science biology.organism_classification 01 natural sciences Biochemistry Cytostasis 0104 chemical sciences Analytical Chemistry law.invention 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Germacrene law Micronucleus test Cytotoxicity Xylopia Essential oil |
| Zdroj: | Natural Product Research. 35:1682-1685 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | Hydro-distilled essential oil from leaves of Xylopia laevigata was characterized by GC-MS. Twenty-seven components were identified and the oil’s major constituents comprised germacrene D, bicyclogermacrene, (E)-caryophyllene and germacrene B. The cytotoxicity of the essential oil of X. laevigata (EOXL), determined by MTT and mitotic index methods in cultured human lymphocytes was observed in all tested concentrations. Cultures treated with EOXL demonstrated significant increase in the frequencies of micronuclei in the cytokinesis-block micronucleus assay (CBMN) and reduction of the cytokinesis-block proliferation index (CBPI) rates. Results demonstrated the cytostatic and mutagenic effects of EOXL, the latter for the first time. |
| Databáze: | OpenAIRE |
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