Topical lomefloxacin twice daily compared with fucidic acid in acute bacterial conjunctivitis
| Autor: | Raija Voutilainen, Marja‐Leena Latvala, Arthur Jauch, Kimmo Malminiemi, Ari Miettinen, Osmo Kari |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Administration Topical Antibiotics Colony Count Microbial Drug Resistance Microbial Sensitivity Tests Quinolones Gastroenterology Conjunctivitis Bacterial 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents Double-Blind Method Recovery rate Internal medicine medicine Humans Clinical efficacy Adverse effect Bacterial Conjunctivitis 0303 health sciences Bacteria 030306 microbiology business.industry Incidence (epidemiology) Anti-Bacterial Agents 3. Good health Ophthalmology Multicenter study Anesthesia Acute Disease 030221 ophthalmology & optometry Lomefloxacin Ophthalmic Solutions business Conjunctiva Fusidic Acid Fluoroquinolones medicine.drug |
| Zdroj: | Acta Ophthalmologica Scandinavica. 74:280-284 |
| ISSN: | 1395-3907 |
| DOI: | 10.1111/j.1600-0420.1996.tb00092.x |
| Popis: | Forty-five patients with presumed acute bacterial conjunctivitis were treated in an investigator-masked randomized multicenter study with either lomefloxacin 0.3% or fucidic acid 1% eye drops twice daily. Clinical signs and symptoms were rated by slit-lamp examination and conjunctival swab cultures were performed to evaluate clinical and microbiological efficacy. A total of 57 ocular isolates were tested for susceptibility to nine antibiotics. A significant decrease in clinical symptomatology was achieved by both treatments with a gradual improvement over the treatment period of 7-9 days. Bacteriological recovery was frequently achieved already at the first control visit (day 3-5), but the recovery rate was statistically significant (p = 0.014) only in the lomefloxacin group. The relatively high in vitro resistance rate (46%) to fucidic acid was not reflected by lower clinical efficacy. Two unrelated adverse events (one in each treatment group) and minimal local intolerance problems were observed in both treatment groups. A significantly higher incidence of burning sensation was observed with fucidic acid than with lomefloxacin (p < 0.01). All four treatment failures in the study occurred in the fucidic acid group. Lomefloxacin 0.3% ophthalmic solution demonstrated a high efficacy and good tolerance in the management of acute bacterial conjunctivitis. |
| Databáze: | OpenAIRE |
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